# Contrastive Representation Learning Helps Cross-institutional Knowledge Transfer: A Study in Pediatric Ventilation Management

arXiv: https://arxiv.org/abs/2501.13587 · HTML: https://mlsanity.com/paper/2501.13587/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 20 references that are in the map.
- First posted on arXiv 23 Jan 2025.

## Builds on (most cited first, 11 of 11)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [Med-BERT: pre-trained contextualized embeddings on large-scale structured electronic health records for disease prediction](https://mlsanity.com/paper/2005.12833/) (2020)
- [Towards Generalist Biomedical AI](https://mlsanity.com/paper/2307.14334/) (2023)
- [Unsupervised Representation Learning for Time Series with Temporal Neighborhood Coding](https://mlsanity.com/paper/2106.00750/) (2021)
- [MIMIC-Extract: A Data Extraction, Preprocessing, and Representation Pipeline for MIMIC-III](https://mlsanity.com/paper/1907.08322/) (2019)
- [EHRSHOT: An EHR Benchmark for Few-Shot Evaluation of Foundation Models](https://mlsanity.com/paper/2307.02028/) (2023)
- [Self-Supervised Learning for Time Series Analysis: Taxonomy, Progress, and Prospects](https://mlsanity.com/paper/2306.10125/) (2023)
- [Causal Contrastive Learning for Counterfactual Regression Over Time](https://mlsanity.com/paper/2406.00535/) (2024)
- [SOM-CPC: Unsupervised Contrastive Learning with Self-Organizing Maps for Structured Representations of High-Rate Time Series](https://mlsanity.com/paper/2205.15875/) (2022)

## Abstract (arXiv)

Clinical machine learning deployment across institutions faces significant challenges when patient populations and clinical practices differ substantially. We present a systematic framework for cross-institutional knowledge transfer in clinical time series, demonstrated through pediatric ventilation management between a general pediatric intensive care unit (PICU) and a cardiac-focused unit. Using contrastive predictive coding (CPC) for representation learning, we investigate how different data regimes and fine-tuning strategies affect knowledge transfer across institutional boundaries. Our results show that while direct model transfer performs poorly, CPC with appropriate fine-tuning enables effective knowledge sharing between institutions, with benefits particularly evident in limited data scenarios. Analysis of transfer patterns reveals an important asymmetry: temporal progression patterns transfer more readily than point-of-care decisions, suggesting practical pathways for cross-institutional deployment. Through a systematic evaluation of fine-tuning approaches and transfer patterns, our work provides insights for developing more generalizable clinical decision support systems while enabling smaller specialized units to leverage knowledge from larger centers.