# SEANN: A Domain-Informed Neural Network for Epidemiological Insights

arXiv: https://arxiv.org/abs/2501.10273 · HTML: https://mlsanity.com/paper/2501.10273/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 27 references that are in the map.
- First posted on arXiv 17 Jan 2025.

## Builds on (most cited first, 4 of 4)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Shortcut Learning in Deep Neural Networks](https://mlsanity.com/paper/2004.07780/) (2020)
- [Informed Machine Learning -- A Taxonomy and Survey of Integrating Knowledge into Learning Systems](https://mlsanity.com/paper/1903.12394/) (2019)
- [Physics-guided Neural Networks (PGNN): An Application in Lake Temperature Modeling](https://mlsanity.com/paper/1710.11431/) (2017)

## Abstract (arXiv)

In epidemiology, traditional statistical methods such as logistic regression, linear regression, and other parametric models are commonly employed to investigate associations between predictors and health outcomes. However, non-parametric machine learning techniques, such as deep neural networks (DNNs), coupled with explainable AI (XAI) tools, offer new opportunities for this task. Despite their potential, these methods face challenges due to the limited availability of high-quality, high-quantity data in this field. To address these challenges, we introduce SEANN, a novel approach for informed DNNs that leverages a prevalent form of domain-specific knowledge: Pooled Effect Sizes (PES). PESs are commonly found in published Meta-Analysis studies, in different forms, and represent a quantitative form of a scientific consensus. By direct integration within the learning procedure using a custom loss, we experimentally demonstrate significant improvements in the generalizability of predictive performances and the scientific plausibility of extracted relationships compared to a domain-knowledge agnostic neural network in a scarce and noisy data setting.