# Agent Laboratory: Using LLM Agents as Research Assistants

arXiv: https://arxiv.org/abs/2501.04227 · HTML: https://mlsanity.com/paper/2501.04227/

## Key facts

- Cited by 425 papers in the map (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 67 of its 114 references that are in the map.
- First posted on arXiv 8 Jan 2025.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 30 of 67)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [GPT-4o System Card](https://mlsanity.com/paper/2410.21276/) (2024)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [RT-2: Vision-Language-Action Models Transfer Web Knowledge to Robotic Control](https://mlsanity.com/paper/2307.15818/) (2023)
- [π0: A Vision-Language-Action Flow Model for General Robot Control](https://mlsanity.com/paper/2410.24164/) (2024)
- [RT-1: Robotics Transformer for Real-World Control at Scale](https://mlsanity.com/paper/2212.06817/) (2022)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [MetaGPT: Meta Programming for A Multi-Agent Collaborative Framework](https://mlsanity.com/paper/2308.00352/) (2023)
- [SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering](https://mlsanity.com/paper/2405.15793/) (2024)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [OpenHands: An Open Platform for AI Software Developers as Generalist Agents](https://mlsanity.com/paper/2407.16741/) (2024)
- [CodeGen: An Open Large Language Model for Code with Multi-Turn Program Synthesis](https://mlsanity.com/paper/2203.13474/) (2022)
- [Large Language Models Can Self-Improve](https://mlsanity.com/paper/2210.11610/) (2022)
- [MLE-bench: Evaluating Machine Learning Agents on Machine Learning Engineering](https://mlsanity.com/paper/2410.07095/) (2024)
- [WebVoyager: Building an End-to-End Web Agent with Large Multimodal Models](https://mlsanity.com/paper/2401.13919/) (2024)
- [AFlow: Automating Agentic Workflow Generation](https://mlsanity.com/paper/2410.10762/) (2024)
- [Automated Design of Agentic Systems](https://mlsanity.com/paper/2408.08435/) (2024)
- [Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers](https://mlsanity.com/paper/2409.04109/) (2024)
- [A Real-World WebAgent with Planning, Long Context Understanding, and Program Synthesis](https://mlsanity.com/paper/2307.12856/) (2023)
- [ScienceAgentBench: Toward Rigorous Assessment of Language Agents for Data-Driven Scientific Discovery](https://mlsanity.com/paper/2410.05080/) (2024)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [AutoAgents: A Framework for Automatic Agent Generation](https://mlsanity.com/paper/2309.17288/) (2023)
- [ResearchAgent: Iterative Research Idea Generation over Scientific Literature with Large Language Models](https://mlsanity.com/paper/2404.07738/) (2024)
- [Agent Q: Advanced Reasoning and Learning for Autonomous AI Agents](https://mlsanity.com/paper/2408.07199/) (2024)

## Built on by (most cited first, 30 of 425)

- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [DeepResearch Bench: A Comprehensive Benchmark for Deep Research Agents](https://mlsanity.com/paper/2506.11763/) (2025)
- [Video models are zero-shot learners and reasoners](https://mlsanity.com/paper/2509.20328/) (2025)
- [From LLM Reasoning to Autonomous AI Agents: A Comprehensive Review](https://mlsanity.com/paper/2504.19678/) (2025)
- [Deep Research Agents: A Systematic Examination And Roadmap](https://mlsanity.com/paper/2506.18096/) (2025)
- [Advances and Challenges in Foundation Agents: From Brain-Inspired Intelligence to Evolutionary, Collaborative, and Safe Systems](https://mlsanity.com/paper/2504.01990/) (2025)
- [Agentic Large Language Models, a survey](https://mlsanity.com/paper/2503.23037/) (2025)
- [How Memory Management Impacts LLM Agents: An Empirical Study of Experience-Following Behavior](https://mlsanity.com/paper/2505.16067/) (2025)
- [AI-Researcher: Autonomous Scientific Innovation](https://mlsanity.com/paper/2505.18705/) (2025)
- [Towards Scientific Intelligence: A Survey of LLM-based Scientific Agents](https://mlsanity.com/paper/2503.24047/) (2025)
- [From Automation to Autonomy: A Survey on Large Language Models in Scientific Discovery](https://mlsanity.com/paper/2505.13259/) (2025)
- [BixBench: a Comprehensive Benchmark for LLM-based Agents in Computational Biology](https://mlsanity.com/paper/2503.00096/) (2025)
- [Agentic AI for Scientific Discovery: A Survey of Progress, Challenges, and Future Directions](https://mlsanity.com/paper/2503.08979/) (2025)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [AgentRxiv: Towards Collaborative Autonomous Research](https://mlsanity.com/paper/2503.18102/) (2025)
- [Open Challenges in Multi-Agent Security: Towards Secure Systems of Interacting AI Agents](https://mlsanity.com/paper/2505.02077/) (2025)
- [Paper2Code: Automating Code Generation from Scientific Papers in Machine Learning](https://mlsanity.com/paper/2504.17192/) (2025)
- [Deep Research: A Survey of Autonomous Research Agents](https://mlsanity.com/paper/2508.12752/) (2025)
- [MLR-Bench: Evaluating AI Agents on Open-Ended Machine Learning Research](https://mlsanity.com/paper/2505.19955/) (2025)
- [DeepScientist: Advancing Frontier-Pushing Scientific Findings Progressively](https://mlsanity.com/paper/2509.26603/) (2025)
- [LLM Agents for Education: Advances and Applications](https://mlsanity.com/paper/2503.11733/) (2025)
- [ZeroBench: An Impossible Visual Benchmark for Contemporary Large Multimodal Models](https://mlsanity.com/paper/2502.09696/) (2025)
- [MLE-STAR: Machine Learning Engineering Agent via Search and Targeted Refinement](https://mlsanity.com/paper/2506.15692/) (2025)
- [Taming Various Privilege Escalation in LLM-Based Agent Systems: A Mandatory Access Control Framework](https://mlsanity.com/paper/2601.11893/) (2026)
- [ScienceBoard: Evaluating Multimodal Autonomous Agents in Realistic Scientific Workflows](https://mlsanity.com/paper/2505.19897/) (2025)
- [From Web Search towards Agentic Deep Research: Incentivizing Search with Reasoning Agents](https://mlsanity.com/paper/2506.18959/) (2025)
- [EvoScientist: Towards Multi-Agent Evolving AI Scientists for End-to-End Scientific Discovery](https://mlsanity.com/paper/2603.08127/) (2026)
- [A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agents](https://mlsanity.com/paper/2601.12538/) (2026)
- [LLM Agents Making Agent Tools](https://mlsanity.com/paper/2502.11705/) (2025)
- [General Agentic Memory Via Deep Research](https://mlsanity.com/paper/2511.18423/) (2025)

## Abstract (arXiv)

Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research quality, we introduce Agent Laboratory, an autonomous LLM-based framework capable of completing the entire research process. This framework accepts a human-provided research idea and progresses through three stages--literature review, experimentation, and report writing to produce comprehensive research outputs, including a code repository and a research report, while enabling users to provide feedback and guidance at each stage. We deploy Agent Laboratory with various state-of-the-art LLMs and invite multiple researchers to assess its quality by participating in a survey, providing human feedback to guide the research process, and then evaluate the final paper. We found that: (1) Agent Laboratory driven by o1-preview generates the best research outcomes; (2) The generated machine learning code is able to achieve state-of-the-art performance compared to existing methods; (3) Human involvement, providing feedback at each stage, significantly improves the overall quality of research; (4) Agent Laboratory significantly reduces research expenses, achieving an 84% decrease compared to previous autonomous research methods. We hope Agent Laboratory enables researchers to allocate more effort toward creative ideation rather than low-level coding and writing, ultimately accelerating scientific discovery.