# Enhancing Contrastive Learning for Retinal Imaging via Adjusted Augmentation Scales

arXiv: https://arxiv.org/abs/2501.02451 · HTML: https://mlsanity.com/paper/2501.02451/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 19 references that are in the map.
- First posted on arXiv 5 Jan 2025.

## Builds on (most cited first, 7 of 7)

- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises](https://mlsanity.com/paper/2008.09104/) (2020)
- [DetCo: Unsupervised Contrastive Learning for Object Detection](https://mlsanity.com/paper/2102.04803/) (2021)
- [Contrastive Self-supervised Learning for Graph Classification](https://mlsanity.com/paper/2009.05923/) (2020)
- [Semi-Supervised Action Recognition with Temporal Contrastive Learning](https://mlsanity.com/paper/2102.02751/) (2021)

## Abstract (arXiv)

Contrastive learning, a prominent approach within self-supervised learning, has demonstrated significant effectiveness in developing generalizable models for various applications involving natural images. However, recent research indicates that these successes do not necessarily extend to the medical imaging domain. In this paper, we investigate the reasons for this suboptimal performance and hypothesize that the dense distribution of medical images poses challenges to the pretext tasks in contrastive learning, particularly in constructing positive and negative pairs. We explore model performance under different augmentation strategies and compare the results to those achieved with strong augmentations. Our study includes six publicly available datasets covering multiple clinically relevant tasks. We further assess the model's generalizability through external evaluations. The model pre-trained with weak augmentation outperforms those with strong augmentation, improving AUROC from 0.838 to 0.848 and AUPR from 0.523 to 0.597 on MESSIDOR2, and showing similar enhancements across other datasets. Our findings suggest that optimizing the scale of augmentation is critical for enhancing the efficacy of contrastive learning in medical imaging.