# RadHop-Net: A Lightweight Radiomics-to-Error Regression for False Positive Reduction In MRI Prostate Cancer Detection

arXiv: https://arxiv.org/abs/2501.02066 · HTML: https://mlsanity.com/paper/2501.02066/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 18 references that are in the map.
- First posted on arXiv 3 Jan 2025.

## Builds on (most cited first, 5 of 5)

- [Retina U-Net: Embarrassingly Simple Exploitation of Segmentation Supervision for Medical Object Detection](https://mlsanity.com/paper/1811.08661/) (2018)
- [End-to-end Prostate Cancer Detection in bpMRI via 3D CNNs: Effects of Attention Mechanisms, Clinical Priori and Decoupled False Positive Reduction](https://mlsanity.com/paper/2101.03244/) (2021)
- [Segmentation of Cardiac Structures via Successive Subspace Learning with Saab Transform from Cine MRI](https://mlsanity.com/paper/2107.10718/) (2021)
- [Enhancing Edge Intelligence with Highly Discriminant LNT Features](https://mlsanity.com/paper/2312.14968/) (2023)
- [PCa-RadHop: A Transparent and Lightweight Feed-forward Method for Clinically Significant Prostate Cancer Segmentation](https://mlsanity.com/paper/2403.15969/) (2024)

## Abstract (arXiv)

Clinically significant prostate cancer (csPCa) is a leading cause of cancer death in men, yet it has a high survival rate if diagnosed early. Bi-parametric MRI (bpMRI) reading has become a prominent screening test for csPCa. However, this process has a high false positive (FP) rate, incurring higher diagnostic costs and patient discomfort. This paper introduces RadHop-Net, a novel and lightweight CNN for FP reduction. The pipeline consists of two stages: Stage 1 employs data driven radiomics to extract candidate ROIs. In contrast, Stage 2 expands the receptive field about each ROI using RadHop-Net to compensate for the predicted error from Stage 1. Moreover, a novel loss function for regression problems is introduced to balance the influence between FPs and true positives (TPs). RadHop-Net is trained in a radiomics-to-error manner, thus decoupling from the common voxel-to-label approach. The proposed Stage 2 improves the average precision (AP) in lesion detection from 0.407 to 0.468 in the publicly available pi-cai dataset, also maintaining a significantly smaller model size than the state-of-the-art.