# EAUWSeg: Eliminating annotation uncertainty in weakly-supervised medical image segmentation

arXiv: https://arxiv.org/abs/2501.01658 · HTML: https://mlsanity.com/paper/2501.01658/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 25 of its 48 references that are in the map.
- First posted on arXiv 3 Jan 2025.

## Builds on (most cited first, 25 of 25)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [ScribbleSup: Scribble-Supervised Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1604.05144/) (2016)
- [TransFuse: Fusing Transformers and CNNs for Medical Image Segmentation](https://mlsanity.com/paper/2102.08005/) (2021)
- [ST++: Make Self-training Work Better for Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2106.05095/) (2021)
- [Semi-Supervised Semantic Segmentation with Pixel-Level Contrastive Learning from a Class-wise Memory Bank](https://mlsanity.com/paper/2104.13415/) (2021)
- [Normalized Cut Loss for Weakly-supervised CNN Segmentation](https://mlsanity.com/paper/1804.01346/) (2018)
- [HiFormer: Hierarchical Multi-scale Representations Using Transformers for Medical Image Segmentation](https://mlsanity.com/paper/2207.08518/) (2022)
- [DeepCut: Object Segmentation from Bounding Box Annotations using Convolutional Neural Networks](https://mlsanity.com/paper/1605.07866/) (2016)
- [CycleMix: A Holistic Strategy for Medical Image Segmentation from Scribble Supervision](https://mlsanity.com/paper/2203.01475/) (2022)
- [TransAttUnet: Multi-level Attention-guided U-Net with Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2107.05274/) (2021)
- [Rethinking Semi-Supervised Medical Image Segmentation: A Variance-Reduction Perspective](https://mlsanity.com/paper/2302.01735/) (2023)
- [Gated CRF Loss for Weakly Supervised Semantic Image Segmentation](https://mlsanity.com/paper/1906.04651/) (2019)
- [Mumford-Shah Loss Functional for Image Segmentation with Deep Learning](https://mlsanity.com/paper/1904.02872/) (2019)
- [ScribbleVC: Scribble-supervised Medical Image Segmentation with Vision-Class Embedding](https://mlsanity.com/paper/2307.16226/) (2023)
- [Inter Extreme Points Geodesics for End-to-End Weakly Supervised Image Segmentation](https://mlsanity.com/paper/2107.00583/) (2021)
- [Contrastive Registration for Unsupervised Medical Image Segmentation](https://mlsanity.com/paper/2011.08894/) (2020)
- [Cross-level Contrastive Learning and Consistency Constraint for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2202.04074/) (2022)
- [Unsupervised Total Variation Loss for Semi-supervised Deep Learning of Semantic Segmentation](https://mlsanity.com/paper/1605.01368/) (2016)
- [Exploring Feature Representation Learning for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2111.10989/) (2021)

## Built on by (most cited first, 1 of 1)

- [Cosine-Normalized Attention for Hyperspectral Image Classification](https://mlsanity.com/paper/2604.01763/) (2026)

## Abstract (arXiv)

Weakly-supervised medical image segmentation is gaining traction as it requires only rough annotations rather than accurate pixel-to-pixel labels, thereby reducing the workload for specialists. Although some progress has been made, there is still a considerable performance gap between the label-efficient methods and fully-supervised one, which can be attributed to the uncertainty nature of these weak labels. To address this issue, we propose a novel weak annotation method coupled with its learning framework EAUWSeg to eliminate the annotation uncertainty. Specifically, we first propose the Bounded Polygon Annotation (BPAnno) by simply labeling two polygons for a lesion. Then, the tailored learning mechanism that explicitly treat bounded polygons as two separated annotations is proposed to learn invariant feature by providing adversarial supervision signal for model training. Subsequently, a confidence-auxiliary consistency learner incorporates with a classification-guided confidence generator is designed to provide reliable supervision signal for pixels in uncertain region by leveraging the feature presentation consistency across pixels within the same category as well as class-specific information encapsulated in bounded polygons annotation. Experimental results demonstrate that EAUWSeg outperforms existing weakly-supervised segmentation methods. Furthermore, compared to fully-supervised counterparts, the proposed method not only delivers superior performance but also costs much less annotation workload. This underscores the superiority and effectiveness of our approach.