# Modality-Projection Universal Model for Comprehensive Full-Body Medical Imaging Segmentation

arXiv: https://arxiv.org/abs/2412.19026 · HTML: https://mlsanity.com/paper/2412.19026/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 37 of its 96 references that are in the map.
- First posted on arXiv 26 Dec 2024.

## Builds on (most cited first, 30 of 37)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [HyperNetworks](https://mlsanity.com/paper/1609.09106/) (2016)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [With a Little Help from My Friends: Nearest-Neighbor Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2104.14548/) (2021)
- [Unsupervised Semantic Segmentation by Distilling Feature Correspondences](https://mlsanity.com/paper/2203.08414/) (2022)
- [Segment Anything in Medical Images](https://mlsanity.com/paper/2304.12306/) (2023)
- [CLIP-Driven Universal Model for Organ Segmentation and Tumor Detection](https://mlsanity.com/paper/2301.00785/) (2023)
- [Unsupervised Semantic Segmentation by Contrasting Object Mask Proposals](https://mlsanity.com/paper/2102.06191/) (2021)
- [BioCLIP: A Vision Foundation Model for the Tree of Life](https://mlsanity.com/paper/2311.18803/) (2023)
- [Unsupervised Learning of Dense Visual Representations](https://mlsanity.com/paper/2011.05499/) (2020)
- [A Brief Review of Hypernetworks in Deep Learning](https://mlsanity.com/paper/2306.06955/) (2023)
- [STU-Net: Scalable and Transferable Medical Image Segmentation Models Empowered by Large-Scale Supervised Pre-training](https://mlsanity.com/paper/2304.06716/) (2023)
- [UniverSeg: Universal Medical Image Segmentation](https://mlsanity.com/paper/2304.06131/) (2023)
- [VISTA3D: A Unified Segmentation Foundation Model For 3D Medical Imaging](https://mlsanity.com/paper/2406.05285/) (2024)
- [TotalSegmentator MRI: Robust Sequence-independent Segmentation of Multiple Anatomic Structures in MRI](https://mlsanity.com/paper/2405.19492/) (2024)
- [AbdomenAtlas-8K: Annotating 8,000 CT Volumes for Multi-Organ Segmentation in Three Weeks](https://mlsanity.com/paper/2305.09666/) (2023)
- [UniSeg: A Prompt-driven Universal Segmentation Model as well as A Strong Representation Learner](https://mlsanity.com/paper/2304.03493/) (2023)
- [MedCLIP-SAM: Bridging Text and Image Towards Universal Medical Image Segmentation](https://mlsanity.com/paper/2403.20253/) (2024)
- [The state-of-the-art 3D anisotropic intracranial hemorrhage segmentation on non-contrast head CT: The INSTANCE challenge](https://mlsanity.com/paper/2301.03281/) (2023)
- [The ULS23 Challenge: a Baseline Model and Benchmark Dataset for 3D Universal Lesion Segmentation in Computed Tomography](https://mlsanity.com/paper/2406.05231/) (2024)
- [Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoising](https://mlsanity.com/paper/2305.15887/) (2023)
- [Learning from partially labeled data for multi-organ and tumor segmentation](https://mlsanity.com/paper/2211.06894/) (2022)

## Abstract (arXiv)

The integration of deep learning in medical imaging has shown great promise for enhancing diagnostic, therapeutic, and research outcomes. However, applying universal models across multiple modalities remains challenging due to the inherent variability in data characteristics. This study aims to introduce and evaluate a Modality Projection Universal Model (MPUM). MPUM employs a novel modality-projection strategy, which allows the model to dynamically adjust its parameters to optimize performance across different imaging modalities. The MPUM demonstrated superior accuracy in identifying anatomical structures, enabling precise quantification for improved clinical decision-making. It also identifies metabolic associations within the brain-body axis, advancing research on brain-body physiological correlations. Furthermore, MPUM's unique controller-based convolution layer enables visualization of saliency maps across all network layers, significantly enhancing the model's interpretability.