# HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs

arXiv: https://arxiv.org/abs/2412.18925 · HTML: https://mlsanity.com/paper/2412.18925/

## Key facts

- Cited by 265 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 71 of its 82 references that are in the map.
- First posted on arXiv 25 Dec 2024.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 30 of 71)

- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Let's Verify Step by Step](https://mlsanity.com/paper/2305.20050/) (2023)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [GPQA: A Graduate-Level Google-Proof Q&A Benchmark](https://mlsanity.com/paper/2311.12022/) (2023)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [Gemma 2: Improving Open Language Models at a Practical Size](https://mlsanity.com/paper/2408.00118/) (2024)
- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Rethinking the Role of Demonstrations: What Makes In-Context Learning Work?](https://mlsanity.com/paper/2202.12837/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Large Language Models Cannot Self-Correct Reasoning Yet](https://mlsanity.com/paper/2310.01798/) (2023)
- [STaR: Bootstrapping Reasoning With Reasoning](https://mlsanity.com/paper/2203.14465/) (2022)
- [Yi: Open Foundation Models by 01.AI](https://mlsanity.com/paper/2403.04652/) (2024)
- [Large Language Models Can Self-Improve](https://mlsanity.com/paper/2210.11610/) (2022)
- [DeepSeek LLM: Scaling Open-Source Language Models with Longtermism](https://mlsanity.com/paper/2401.02954/) (2024)
- [WizardMath: Empowering Mathematical Reasoning for Large Language Models via Reinforced Evol-Instruct](https://mlsanity.com/paper/2308.09583/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [LLaVA-CoT: Let Vision Language Models Reason Step-by-Step](https://mlsanity.com/paper/2411.10440/) (2024)
- [CMMLU: Measuring massive multitask language understanding in Chinese](https://mlsanity.com/paper/2306.09212/) (2023)
- [Training Language Models to Self-Correct via Reinforcement Learning](https://mlsanity.com/paper/2409.12917/) (2024)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [The Curse of Recursion: Training on Generated Data Makes Models Forget](https://mlsanity.com/paper/2305.17493/) (2023)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)

## Built on by (most cited first, 30 of 265)

- [Search-o1: Agentic Search-Enhanced Large Reasoning Models](https://mlsanity.com/paper/2501.05366/) (2025)
- [Towards Reasoning Era: A Survey of Long Chain-of-Thought for Reasoning Large Language Models](https://mlsanity.com/paper/2503.09567/) (2025)
- [Rubrics as Rewards: Reinforcement Learning Beyond Verifiable Domains](https://mlsanity.com/paper/2507.17746/) (2025)
- [From System 1 to System 2: A Survey of Reasoning Large Language Models](https://mlsanity.com/paper/2502.17419/) (2025)
- [Self-Distillation Enables Continual Learning](https://mlsanity.com/paper/2601.19897/) (2026)
- [Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning](https://mlsanity.com/paper/2506.07044/) (2025)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [The Landscape of Agentic Reinforcement Learning for LLMs: A Survey](https://mlsanity.com/paper/2509.02547/) (2025)
- [A Survey of Reinforcement Learning for Large Reasoning Models](https://mlsanity.com/paper/2509.08827/) (2025)
- [Crossing the Reward Bridge: Expanding RL with Verifiable Rewards Across Diverse Domains](https://mlsanity.com/paper/2503.23829/) (2025)
- [OpenRubrics: Towards Scalable Synthetic Rubric Generation for Reward Modeling and LLM Alignment](https://mlsanity.com/paper/2510.07743/) (2025)
- [MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs](https://mlsanity.com/paper/2504.00993/) (2025)
- [JudgeLRM: Large Reasoning Models as a Judge](https://mlsanity.com/paper/2504.00050/) (2025)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [RedStar: Does Scaling Long-CoT Data Unlock Better Slow-Reasoning Systems?](https://mlsanity.com/paper/2501.11284/) (2025)
- [Baichuan-M2: Scaling Medical Capability with Large Verifier System](https://mlsanity.com/paper/2509.02208/) (2025)
- [Look-Back: Implicit Visual Re-focusing in MLLM Reasoning](https://mlsanity.com/paper/2507.03019/) (2025)
- [Agentic Reward Modeling: Integrating Human Preferences with Verifiable Correctness Signals for Reliable Reward Systems](https://mlsanity.com/paper/2502.19328/) (2025)
- [A Survey on the Optimization of Large Language Model-based Agents](https://mlsanity.com/paper/2503.12434/) (2025)
- [m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models](https://mlsanity.com/paper/2504.00869/) (2025)
- [VerIF: Verification Engineering for Reinforcement Learning in Instruction Following](https://mlsanity.com/paper/2506.09942/) (2025)
- [Baichuan-M1: Pushing the Medical Capability of Large Language Models](https://mlsanity.com/paper/2502.12671/) (2025)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [MedCaseReasoning: Evaluating and learning diagnostic reasoning from clinical case reports](https://mlsanity.com/paper/2505.11733/) (2025)
- [Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL](https://mlsanity.com/paper/2505.17952/) (2025)
- [Fino1: On the Transferability of Reasoning-Enhanced LLMs and Reinforcement Learning to Finance](https://mlsanity.com/paper/2502.08127/) (2025)
- [LLMEval-Med: A Real-world Clinical Benchmark for Medical LLMs with Physician Validation](https://mlsanity.com/paper/2506.04078/) (2025)
- [ChestX-Reasoner: Advancing Radiology Foundation Models with Reasoning through Step-by-Step Verification](https://mlsanity.com/paper/2504.20930/) (2025)
- [X-Reasoner: Towards Generalizable Reasoning Across Modalities and Domains](https://mlsanity.com/paper/2505.03981/) (2025)
- [Real-World Doctor Agent with Proactive Consultation through Multi-Agent Reinforcement Learning](https://mlsanity.com/paper/2505.19630/) (2025)

## Abstract (arXiv)

The breakthrough of OpenAI o1 highlights the potential of enhancing reasoning to improve LLM. Yet, most research in reasoning has focused on mathematical tasks, leaving domains like medicine underexplored. The medical domain, though distinct from mathematics, also demands robust reasoning to provide reliable answers, given the high standards of healthcare. However, verifying medical reasoning is challenging, unlike those in mathematics. To address this, we propose verifiable medical problems with a medical verifier to check the correctness of model outputs. This verifiable nature enables advancements in medical reasoning through a two-stage approach: (1) using the verifier to guide the search for a complex reasoning trajectory for fine-tuning LLMs, (2) applying reinforcement learning (RL) with verifier-based rewards to enhance complex reasoning further. Finally, we introduce HuatuoGPT-o1, a medical LLM capable of complex reasoning, which outperforms general and medical-specific baselines using only 40K verifiable problems. Experiments show complex reasoning improves medical problem-solving and benefits more from RL. We hope our approach inspires advancements in reasoning across medical and other specialized domains.