# BS-LDM: Effective Bone Suppression in High-Resolution Chest X-Ray Images with Conditional Latent Diffusion Models

arXiv: https://arxiv.org/abs/2412.15670 · HTML: https://mlsanity.com/paper/2412.15670/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 27 of its 63 references that are in the map.
- First posted on arXiv 20 Dec 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 27 of 27)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Perceptual Losses for Real-Time Style Transfer and Super-Resolution](https://mlsanity.com/paper/1603.08155/) (2016)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANs](https://mlsanity.com/paper/1711.11585/) (2017)
- [Latent Consistency Models: Synthesizing High-Resolution Images with Few-Step Inference](https://mlsanity.com/paper/2310.04378/) (2023)
- [ControlNet++: Improving Conditional Controls with Efficient Consistency Feedback](https://mlsanity.com/paper/2404.07987/) (2024)
- [Scalable Diffusion Models with State Space Backbone](https://mlsanity.com/paper/2402.05608/) (2024)
- [Cascaded Latent Diffusion Models for High-Resolution Chest X-ray Synthesis](https://mlsanity.com/paper/2303.11224/) (2023)
- [Morphology-preserving Autoregressive 3D Generative Modelling of the Brain](https://mlsanity.com/paper/2209.03177/) (2022)
- [A Lightweight CNN Model for Detecting Respiratory Diseases from Lung Auscultation Sounds using EMD-CWT-based Hybrid Scalogram](https://mlsanity.com/paper/2009.04402/) (2020)
- [Chest X-Ray Bone Suppression for Improving Classification of Tuberculosis-Consistent Findings](https://mlsanity.com/paper/2104.04518/) (2021)
- [Generation of Virtual Dual Energy Images from Standard Single-Shot Radiographs using Multi-scale and Conditional Adversarial Network](https://mlsanity.com/paper/1810.09354/) (2018)
- [BS-Diff: Effective Bone Suppression Using Conditional Diffusion Models from Chest X-Ray Images](https://mlsanity.com/paper/2311.15328/) (2023)
- [LPUWF-LDM: Enhanced Latent Diffusion Model for Precise Late-phase UWF-FA Generation on Limited Dataset](https://mlsanity.com/paper/2409.00726/) (2024)

## Built on by (most cited first, 4 of 4)

- [ContextFlow: Training-Free Video Object Editing via Adaptive Context Enrichment](https://mlsanity.com/paper/2509.17818/) (2025)
- [GL-LCM: Global-Local Latent Consistency Models for Fast High-Resolution Bone Suppression in Chest X-Ray Images](https://mlsanity.com/paper/2508.03357/) (2025)
- [WeatherRemover: All-in-one Adverse Weather Removal with Multi-scale Feature Map Compression](https://mlsanity.com/paper/2604.06623/) (2026)
- [DeBoneDiT: Depth-Driven Conditional Bridge Diffusion Transformers for Bone Suppression in Chest X-Ray Images](https://mlsanity.com/paper/2610.19466/) (2026)

## Abstract (arXiv)

Lung diseases represent a significant global health challenge, with Chest X-Ray (CXR) being a key diagnostic tool due to its accessibility and affordability. Nonetheless, the detection of pulmonary lesions is often hindered by overlapping bone structures in CXR images, leading to potential misdiagnoses. To address this issue, we develop an end-to-end framework called BS-LDM, designed to effectively suppress bone in high-resolution CXR images. This framework is based on conditional latent diffusion models and incorporates a multi-level hybrid loss-constrained vector-quantized generative adversarial network which is crafted for perceptual compression, ensuring the preservation of details. To further enhance the framework's performance, we utilize offset noise in the forward process, and a temporal adaptive thresholding strategy in the reverse process. These additions help minimize discrepancies in generating low-frequency information of soft tissue images. Additionally, we have compiled a high-quality bone suppression dataset named SZCH-X-Rays. This dataset includes 818 pairs of high-resolution CXR and soft tissue images collected from our partner hospital. Moreover, we processed 241 data pairs from the JSRT dataset into negative images, which are more commonly used in clinical practice. Our comprehensive experiments and downstream evaluations reveal that BS-LDM excels in bone suppression, underscoring its clinical value. Our code is available at https://github.com/diaoquesang/BS-LDM.