# Diffusion priors for Bayesian 3D reconstruction from incomplete measurements

arXiv: https://arxiv.org/abs/2412.14897 · HTML: https://mlsanity.com/paper/2412.14897/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Inverse problems and image restoration, one of 14 directions in Diffusion models.
- Builds on 26 of its 42 references that are in the map.
- First posted on arXiv 19 Dec 2024.

## Placed in

- Diffusion models / [Inverse problems and image restoration](https://mlsanity.com/diffusion/inverse-problems-and-image-restoration/)

## Builds on (most cited first, 26 of 26)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [ShapeNet: An Information-Rich 3D Model Repository](https://mlsanity.com/paper/1512.03012/) (2015)
- [Fast Graph Representation Learning with PyTorch Geometric](https://mlsanity.com/paper/1903.02428/) (2019)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Diffusion Probabilistic Models for 3D Point Cloud Generation](https://mlsanity.com/paper/2103.01458/) (2021)
- [Point-E: A System for Generating 3D Point Clouds from Complex Prompts](https://mlsanity.com/paper/2212.08751/) (2022)
- [One-2-3-45: Any Single Image to 3D Mesh in 45 Seconds without Per-Shape Optimization](https://mlsanity.com/paper/2306.16928/) (2023)
- [LION: Latent Point Diffusion Models for 3D Shape Generation](https://mlsanity.com/paper/2210.06978/) (2022)
- [3D Shape Generation and Completion through Point-Voxel Diffusion](https://mlsanity.com/paper/2104.03670/) (2021)
- [Zero-Shot Text-Guided Object Generation with Dream Fields](https://mlsanity.com/paper/2112.01455/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [Shap-E: Generating Conditional 3D Implicit Functions](https://mlsanity.com/paper/2305.02463/) (2023)
- [Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem](https://mlsanity.com/paper/2206.04119/) (2022)
- [Practical and Asymptotically Exact Conditional Sampling in Diffusion Models](https://mlsanity.com/paper/2306.17775/) (2023)
- [Solving Inverse Problems with Latent Diffusion Models via Hard Data Consistency](https://mlsanity.com/paper/2307.08123/) (2023)
- [HyperDiffusion: Generating Implicit Neural Fields with Weight-Space Diffusion](https://mlsanity.com/paper/2303.17015/) (2023)
- [PC2: Projection-Conditioned Point Cloud Diffusion for Single-Image 3D Reconstruction](https://mlsanity.com/paper/2302.10668/) (2023)
- [Monte Carlo guided Diffusion for Bayesian linear inverse problems](https://mlsanity.com/paper/2308.07983/) (2023)
- [Diffusion Posterior Sampling is Computationally Intractable](https://mlsanity.com/paper/2402.12727/) (2024)
- [Bayesian Diffusion Models for 3D Shape Reconstruction](https://mlsanity.com/paper/2403.06973/) (2024)

## Built on by (most cited first, 1 of 1)

- [Generative Shape Reconstruction with Geometry-Guided Langevin Dynamics](https://mlsanity.com/paper/2603.27016/) (2026)

## Abstract (arXiv)

Many inverse problems are ill-posed and need to be complemented by prior information that restricts the class of admissible models. Bayesian approaches encode this information as prior distributions that impose generic properties on the model such as sparsity, non-negativity or smoothness. However, in case of complex structured models such as images, graphs or three-dimensional (3D) objects,generic prior distributions tend to favor models that differ largely from those observed in the real world. Here we explore the use of diffusion models as priors that are combined with experimental data within a Bayesian framework. We use 3D point clouds to represent 3D objects such as household items or biomolecular complexes formed from proteins and nucleic acids. We train diffusion models that generate coarse-grained 3D structures at a medium resolution and integrate these with incomplete and noisy experimental data. To demonstrate the power of our approach, we focus on the reconstruction of biomolecular assemblies from cryo-electron microscopy (cryo-EM) images, which is an important inverse problem in structural biology. We find that posterior sampling with diffusion model priors allows for 3D reconstruction from very sparse, low-resolution and partial observations.