# MedMax: Mixed-Modal Instruction Tuning for Training Biomedical Assistants

arXiv: https://arxiv.org/abs/2412.12661 · HTML: https://mlsanity.com/paper/2412.12661/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Builds on 55 of its 72 references that are in the map.
- First posted on arXiv 17 Dec 2024.

## Builds on (most cited first, 30 of 55)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [GPT-4o System Card](https://mlsanity.com/paper/2410.21276/) (2024)
- [Improved Baselines with Visual Instruction Tuning](https://mlsanity.com/paper/2310.03744/) (2023)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [Finetuned Language Models Are Zero-Shot Learners](https://mlsanity.com/paper/2109.01652/) (2021)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Neural Machine Translation of Rare Words with Subword Units](https://mlsanity.com/paper/1508.07909/) (2015)
- [LLaVA-OneVision: Easy Visual Task Transfer](https://mlsanity.com/paper/2408.03326/) (2024)
- [MiniGPT-4: Enhancing Vision-Language Understanding with Advanced Large Language Models](https://mlsanity.com/paper/2304.10592/) (2023)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGI](https://mlsanity.com/paper/2311.16502/) (2023)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Tulu 3: Pushing Frontiers in Open Language Model Post-Training](https://mlsanity.com/paper/2411.15124/) (2024)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Chameleon: Mixed-Modal Early-Fusion Foundation Models](https://mlsanity.com/paper/2405.09818/) (2024)
- [Emu3: Next-Token Prediction is All You Need](https://mlsanity.com/paper/2409.18869/) (2024)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographs](https://mlsanity.com/paper/1901.07042/) (2019)
- [OpenFlamingo: An Open-Source Framework for Training Large Autoregressive Vision-Language Models](https://mlsanity.com/paper/2308.01390/) (2023)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [Image as a Foreign Language: BEiT Pretraining for All Vision and Vision-Language Tasks](https://mlsanity.com/paper/2208.10442/) (2022)
- [Transfusion: Predict the Next Token and Diffuse Images with One Multi-Modal Model](https://mlsanity.com/paper/2408.11039/) (2024)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answering](https://mlsanity.com/paper/2305.10415/) (2023)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)

## Built on by (most cited first, 6 of 6)

- [OmniCT: Towards a Unified Slice-Volume LVLM for Comprehensive CT Analysis](https://mlsanity.com/paper/2602.16110/) (2026)
- [LLMs Outperform Experts on Challenging Biology Benchmarks](https://mlsanity.com/paper/2505.06108/) (2025)
- [Mediator-Guided Multi-Agent Collaboration among Open-Source Models for Medical Decision-Making](https://mlsanity.com/paper/2508.05996/) (2025)
- [EndoCogniAgent: Closed-Loop Agentic Reasoning with Self-Consistency Validation for Endoscopic Diagnosis](https://mlsanity.com/paper/2508.07292/) (2025)
- [Beyond a Single Frame: Multi-Frame Spatially Grounded Reasoning Across Volumetric MRI](https://mlsanity.com/paper/2604.15808/) (2026)
- [Aloe-Vision: Robust Vision-Language Models for Healthcare](https://mlsanity.com/paper/2606.27500/) (2026)

## Abstract (arXiv)

Recent advancements in mixed-modal generative have opened new avenues for developing unified biomedical assistants capable of analyzing biomedical images, answering complex questions about them, and generating multimodal patient reports. However, existing datasets face challenges such as small sizes, limited coverage of biomedical tasks and domains, and a reliance on narrow sources. To address these gaps, we present MedMax, a large-scale multimodal biomedical instruction-tuning dataset for mixed-modal foundation models. With 1.47 million instances, MedMax encompasses a diverse range of tasks, including interleaved image-text generation, biomedical image captioning and generation, visual chat, and report understanding. These tasks span knowledge across diverse biomedical domains, including radiology and histopathology, grounded in medical papers and YouTube videos. Subsequently, we fine-tune a mixed-modal foundation model on the MedMax dataset, achieving significant performance improvements: a 26% gain over the Chameleon model and an 18.3% improvement over GPT-4o across 12 downstream biomedical visual question-answering tasks. Finally, we introduce a unified evaluation suite for biomedical tasks to guide the development of mixed-modal biomedical AI assistants. The data, model, and code is available at https://mint-medmax.github.io/.