# Panacea: Novel DNN Accelerator using Accuracy-Preserving Asymmetric Quantization and Energy-Saving Bit-Slice Sparsity

arXiv: https://arxiv.org/abs/2412.10059 · HTML: https://mlsanity.com/paper/2412.10059/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 51 of its 82 references that are in the map.
- First posted on arXiv 13 Dec 2024.

## Builds on (most cited first, 30 of 51)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [GLUE: A Multi-Task Benchmark and Analysis Platform for Natural Language Understanding](https://mlsanity.com/paper/1804.07461/) (2018)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [Pointer Sentinel Mixture Models](https://mlsanity.com/paper/1609.07843/) (2016)
- [Learning both Weights and Connections for Efficient Neural Networks](https://mlsanity.com/paper/1506.02626/) (2015)
- [Quantization and Training of Neural Networks for Efficient Integer-Arithmetic-Only Inference](https://mlsanity.com/paper/1712.05877/) (2017)
- [SmoothQuant: Accurate and Efficient Post-Training Quantization for Large Language Models](https://mlsanity.com/paper/2211.10438/) (2022)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [SparseGPT: Massive Language Models Can Be Accurately Pruned in One-Shot](https://mlsanity.com/paper/2301.00774/) (2023)
- [A Survey of Quantization Methods for Efficient Neural Network Inference](https://mlsanity.com/paper/2103.13630/) (2021)
- [DoReFa-Net: Training Low Bitwidth Convolutional Neural Networks with Low Bitwidth Gradients](https://mlsanity.com/paper/1606.06160/) (2016)
- [BRECQ: Pushing the Limit of Post-Training Quantization by Block Reconstruction](https://mlsanity.com/paper/2102.05426/) (2021)
- [A White Paper on Neural Network Quantization](https://mlsanity.com/paper/2106.08295/) (2021)
- [Efficient Processing of Deep Neural Networks: A Tutorial and Survey](https://mlsanity.com/paper/1703.09039/) (2017)
- [OmniQuant: Omnidirectionally Calibrated Quantization for Large Language Models](https://mlsanity.com/paper/2308.13137/) (2023)
- [Post-Training Quantization for Vision Transformer](https://mlsanity.com/paper/2106.14156/) (2021)
- [ZeroQ: A Novel Zero Shot Quantization Framework](https://mlsanity.com/paper/2001.00281/) (2020)
- [I-BERT: Integer-only BERT Quantization](https://mlsanity.com/paper/2101.01321/) (2021)
- [Edge Intelligence: Paving the Last Mile of Artificial Intelligence with Edge Computing](https://mlsanity.com/paper/1905.10083/) (2019)
- [QServe: W4A8KV4 Quantization and System Co-design for Efficient LLM Serving](https://mlsanity.com/paper/2405.04532/) (2024)
- [Outlier Suppression: Pushing the Limit of Low-bit Transformer Language Models](https://mlsanity.com/paper/2209.13325/) (2022)
- [PTQ4ViT: Post-training quantization for vision transformers with twin uniform quantization](https://mlsanity.com/paper/2111.12293/) (2021)
- [FQ-ViT: Post-Training Quantization for Fully Quantized Vision Transformer](https://mlsanity.com/paper/2111.13824/) (2021)
- [RepQ-ViT: Scale Reparameterization for Post-Training Quantization of Vision Transformers](https://mlsanity.com/paper/2212.08254/) (2022)

## Built on by (most cited first, 5 of 5)

- [MCBP: A Memory-Compute Efficient LLM Inference Accelerator Leveraging Bit-Slice-enabled Sparsity and Repetitiveness](https://mlsanity.com/paper/2509.10372/) (2025)
- [Automating Hardware Design and Verification from Architectural Papers via a Neural-Symbolic Graph Framework](https://mlsanity.com/paper/2511.06067/) (2025)
- [BitStopper: An Efficient Transformer Attention Accelerator via Stage-fusion and Early Termination](https://mlsanity.com/paper/2512.06457/) (2025)
- [ELMoE-3D: Leveraging Intrinsic Elasticity of MoE for Hybrid-Bonding-Enabled Self-Speculative Decoding in On-Premises Serving](https://mlsanity.com/paper/2604.14626/) (2026)
- [GyRot: Leveraging Hidden Synergy between Rotation and Fine-grained Group Quantization for Low-bit LLM Inference](https://mlsanity.com/paper/2607.27694/) (2026)

## Abstract (arXiv)

Low bit-precisions and their bit-slice sparsity have recently been studied to accelerate general matrix-multiplications (GEMM) during large-scale deep neural network (DNN) inferences. While the conventional symmetric quantization facilitates low-resolution processing with bit-slice sparsity for both weight and activation, its accuracy loss caused by the activation's asymmetric distributions cannot be acceptable, especially for large-scale DNNs. In efforts to mitigate this accuracy loss, recent studies have actively utilized asymmetric quantization for activations without requiring additional operations. However, the cutting-edge asymmetric quantization produces numerous nonzero slices that cannot be compressed and skipped by recent bit-slice GEMM accelerators, naturally consuming more processing energy to handle the quantized DNN models. To simultaneously achieve high accuracy and hardware efficiency for large-scale DNN inferences, this paper proposes an Asymmetrically-Quantized bit-Slice GEMM (AQS-GEMM) for the first time. In contrast to the previous bit-slice computing, which only skips operations of zero slices, the AQS-GEMM compresses frequent nonzero slices, generated by asymmetric quantization, and skips their operations. To increase the slice-level sparsity of activations, we also introduce two algorithm-hardware co-optimization methods: a zero-point manipulation and a distribution-based bit-slicing. To support the proposed AQS-GEMM and optimizations at the hardware-level, we newly introduce a DNN accelerator, Panacea, which efficiently handles sparse/dense workloads of the tiled AQS-GEMM to increase data reuse and utilization. Panacea supports a specialized dataflow and run-length encoding to maximize data reuse and minimize external memory accesses, significantly improving its hardware efficiency. Our benchmark evaluations show Panacea outperforms existing DNN accelerators.