# Optimized Vessel Segmentation: A Structure-Agnostic Approach with Small Vessel Enhancement and Morphological Correction

arXiv: https://arxiv.org/abs/2411.15251 · HTML: https://mlsanity.com/paper/2411.15251/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 42 of its 85 references that are in the map.
- First posted on arXiv 22 Nov 2024.

## Builds on (most cited first, 30 of 42)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [Segment Anything in High Quality](https://mlsanity.com/paper/2306.01567/) (2023)
- [clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation](https://mlsanity.com/paper/2003.07311/) (2020)
- [Customized Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.13785/) (2023)
- [CE-Net: Context Encoder Network for 2D Medical Image Segmentation](https://mlsanity.com/paper/1903.02740/) (2019)
- [Topology-Preserving Deep Image Segmentation](https://mlsanity.com/paper/1906.05404/) (2019)
- [Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation](https://mlsanity.com/paper/1802.06955/) (2018)
- [Large-scale Multi-Modal Pre-trained Models: A Comprehensive Survey](https://mlsanity.com/paper/2302.10035/) (2023)
- [DoubleU-Net: A Deep Convolutional Neural Network for Medical Image Segmentation](https://mlsanity.com/paper/2006.04868/) (2020)
- [SAM-Med2D](https://mlsanity.com/paper/2308.16184/) (2023)
- [Synergistic Image and Feature Adaptation: Towards Cross-Modality Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/1901.08211/) (2019)
- [Annotation-efficient deep learning for automatic medical image segmentation](https://mlsanity.com/paper/2012.04885/) (2020)
- [ROSE: A Retinal OCT-Angiography Vessel Segmentation Dataset and New Model](https://mlsanity.com/paper/2007.05201/) (2020)
- [SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentation](https://mlsanity.com/paper/2004.03696/) (2020)
- [CS2-Net: Deep Learning Segmentation of Curvilinear Structures in Medical Imaging](https://mlsanity.com/paper/2010.07486/) (2020)
- [OCTA-500: A Retinal Dataset for Optical Coherence Tomography Angiography Study](https://mlsanity.com/paper/2012.07261/) (2020)
- [How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Model](https://mlsanity.com/paper/2404.09957/) (2024)
- [Towards a glaucoma risk index based on simulated hemodynamics from fundus images](https://mlsanity.com/paper/1805.10273/) (2018)
- [Directional Connectivity-based Segmentation of Medical Images](https://mlsanity.com/paper/2304.00145/) (2023)
- [SegRefiner: Towards Model-Agnostic Segmentation Refinement with Discrete Diffusion Process](https://mlsanity.com/paper/2312.12425/) (2023)
- [Ladder Fine-tuning approach for SAM integrating complementary network](https://mlsanity.com/paper/2306.12737/) (2023)

## Abstract (arXiv)

Accurate segmentation of blood vessels is essential for various clinical assessments and postoperative analyses. However, the inherent challenges of vascular imaging, such as sparsity, fine granularity, low contrast, data distribution variability, and the critical need for preserving topological structure, making generalized vessel segmentation particularly complex. While specialized segmentation methods have been developed for specific anatomical regions, their over-reliance on tailored models hinders broader applicability and generalization. General-purpose segmentation models introduced in medical imaging often fail to address critical vascular characteristics, including the connectivity of segmentation results. To overcome these limitations, we propose an optimized vessel segmentation framework: a structure-agnostic approach incorporating small vessel enhancement and morphological correction for multi-modality vessel segmentation. To train and validate this framework, we compiled a comprehensive multi-modality dataset spanning 17 datasets and benchmarked our model against six SAM-based methods and 17 expert models. The results demonstrate that our approach achieves superior segmentation accuracy, generalization, and a 34.6% improvement in connectivity, underscoring its clinical potential. An ablation study further validates the effectiveness of the proposed improvements. We will release the code and dataset at github following the publication of this work.