# CCIS-Diff: A Generative Model with Stable Diffusion Prior for Controlled Colonoscopy Image Synthesis

arXiv: https://arxiv.org/abs/2411.12198 · HTML: https://mlsanity.com/paper/2411.12198/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 11 of its 16 references that are in the map.
- First posted on arXiv 19 Nov 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 11 of 11)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [PraNet: Parallel Reverse Attention Network for Polyp Segmentation](https://mlsanity.com/paper/2006.11392/) (2020)
- [Uni-ControlNet: All-in-One Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2305.16322/) (2023)
- [A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Images](https://mlsanity.com/paper/1612.00799/) (2016)
- [Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformers](https://mlsanity.com/paper/2108.06932/) (2021)
- [ArSDM: Colonoscopy Images Synthesis with Adaptive Refinement Semantic Diffusion Models](https://mlsanity.com/paper/2309.01111/) (2023)

## Built on by (most cited first, 6 of 6)

- [Universal Visuo-Tactile Video Understanding for Embodied Interaction](https://mlsanity.com/paper/2505.22566/) (2025)
- [A Review of Human Emotion Synthesis Based on Generative Technology](https://mlsanity.com/paper/2412.07116/) (2024)
- [PPS-Ctrl: Controllable Sim-to-Real Translation for Colonoscopy Depth Estimation](https://mlsanity.com/paper/2504.17067/) (2025)
- [ColoDiff: Integrating Dynamic Consistency With Content Awareness for Colonoscopy Video Generation](https://mlsanity.com/paper/2602.23203/) (2026)
- [One-shot synthesis of rare gastrointestinal lesions improves diagnostic accuracy and clinical training](https://mlsanity.com/paper/2512.24278/) (2025)
- [E^2-LLM: Bridging Neural Signals and Interpretable Affective Analysis](https://mlsanity.com/paper/2601.07877/) (2026)

## Abstract (arXiv)

Colonoscopy is crucial for identifying adenomatous polyps and preventing colorectal cancer. However, developing robust models for polyp detection is challenging by the limited size and accessibility of existing colonoscopy datasets. While previous efforts have attempted to synthesize colonoscopy images, current methods suffer from instability and insufficient data diversity. Moreover, these approaches lack precise control over the generation process, resulting in images that fail to meet clinical quality standards. To address these challenges, we propose CCIS-DIFF, a Controlled generative model for high-quality Colonoscopy Image Synthesis based on a Diffusion architecture. Our method offers precise control over both the spatial attributes (polyp location and shape) and clinical characteristics of polyps that align with clinical descriptions. Specifically, we introduce a blur mask weighting strategy to seamlessly blend synthesized polyps with the colonic mucosa, and a text-aware attention mechanism to guide the generated images to reflect clinical characteristics. Notably, to achieve this, we construct a new multi-modal colonoscopy dataset that integrates images, mask annotations, and corresponding clinical text descriptions. Experimental results demonstrate that our method generates high-quality, diverse colonoscopy images with fine control over both spatial constraints and clinical consistency, offering valuable support for downstream segmentation and diagnostic tasks.