# Robust Divergence Learning for Missing-Modality Segmentation

arXiv: https://arxiv.org/abs/2411.08305 · HTML: https://mlsanity.com/paper/2411.08305/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 10 references that are in the map.
- First posted on arXiv 13 Nov 2024.

## Builds on (most cited first, 6 of 6)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Annotation-efficient deep learning for automatic medical image segmentation](https://mlsanity.com/paper/2012.04885/) (2020)
- [M3AE: Multimodal Representation Learning for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2303.05302/) (2023)
- [SMU-Net: Style matching U-Net for brain tumor segmentation with missing modalities](https://mlsanity.com/paper/2204.02961/) (2022)
- [Gradient-Guided Modality Decoupling for Missing-Modality Robustness](https://mlsanity.com/paper/2402.16318/) (2024)
- [On H"older projective divergences](https://mlsanity.com/paper/1701.03916/) (2017)

## Built on by (most cited first, 1 of 1)

- [Robust Brain Tumor Segmentation with Incomplete MRI Modalities Using H"older Divergence and Mutual Information-Enhanced Knowledge Transfer](https://mlsanity.com/paper/2507.01254/) (2025)

## Abstract (arXiv)

Multimodal Magnetic Resonance Imaging (MRI) provides essential complementary information for analyzing brain tumor subregions. While methods using four common MRI modalities for automatic segmentation have shown success, they often face challenges with missing modalities due to image quality issues, inconsistent protocols, allergic reactions, or cost factors. Thus, developing a segmentation paradigm that handles missing modalities is clinically valuable. A novel single-modality parallel processing network framework based on H"older divergence and mutual information is introduced. Each modality is independently input into a shared network backbone for parallel processing, preserving unique information. Additionally, a dynamic sharing framework is introduced that adjusts network parameters based on modality availability. A H"older divergence and mutual information-based loss functions are used for evaluating discrepancies between predictions and labels. Extensive testing on the BraTS 2018 and BraTS 2020 datasets demonstrates that our method outperforms existing techniques in handling missing modalities and validates each component's effectiveness.