# Arctique: An artificial histopathological dataset unifying realism and controllability for uncertainty quantification

arXiv: https://arxiv.org/abs/2411.07097 · HTML: https://mlsanity.com/paper/2411.07097/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 27 of its 42 references that are in the map.
- First posted on arXiv 11 Nov 2024.

## Builds on (most cited first, 27 of 27)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Simple and Scalable Predictive Uncertainty Estimation using Deep Ensembles](https://mlsanity.com/paper/1612.01474/) (2016)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [What Uncertainties Do We Need in Bayesian Deep Learning for Computer Vision?](https://mlsanity.com/paper/1703.04977/) (2017)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [A Review of Uncertainty Quantification in Deep Learning: Techniques, Applications and Challenges](https://mlsanity.com/paper/2011.06225/) (2020)
- [A Survey of Uncertainty in Deep Neural Networks](https://mlsanity.com/paper/2107.03342/) (2021)
- [Aleatoric uncertainty estimation with test-time augmentation for medical image segmentation with convolutional neural networks](https://mlsanity.com/paper/1807.07356/) (2018)
- [Deep Deterministic Uncertainty: A Simple Baseline](https://mlsanity.com/paper/2102.11582/) (2021)
- [Evaluating Scalable Bayesian Deep Learning Methods for Robust Computer Vision](https://mlsanity.com/paper/1906.01620/) (2019)
- [Evaluating Bayesian Deep Learning Methods for Semantic Segmentation](https://mlsanity.com/paper/1811.12709/) (2018)
- [Lizard: A Large-Scale Dataset for Colonic Nuclear Instance Segmentation and Classification](https://mlsanity.com/paper/2108.11195/) (2021)
- [On the Practicality of Deterministic Epistemic Uncertainty](https://mlsanity.com/paper/2107.00649/) (2021)
- [FunnyBirds: A Synthetic Vision Dataset for a Part-Based Analysis of Explainable AI Methods](https://mlsanity.com/paper/2308.06248/) (2023)
- [Benchmarking Bayesian Deep Learning on Diabetic Retinopathy Detection Tasks](https://mlsanity.com/paper/2211.12717/) (2022)
- [Is segmentation uncertainty useful?](https://mlsanity.com/paper/2103.16265/) (2021)
- [Multi-Task Domain Adaptation for Deep Learning of Instance Grasping from Simulation](https://mlsanity.com/paper/1710.06422/) (2017)
- [NuInsSeg: A Fully Annotated Dataset for Nuclei Instance Segmentation in H&E-Stained Histological Images](https://mlsanity.com/paper/2308.01760/) (2023)
- [ValUES: A Framework for Systematic Validation of Uncertainty Estimation in Semantic Segmentation](https://mlsanity.com/paper/2401.08501/) (2024)
- [Active One-shot Learning](https://mlsanity.com/paper/1702.06559/) (2017)
- [Tyche: Stochastic In-Context Learning for Medical Image Segmentation](https://mlsanity.com/paper/2401.13650/) (2024)
- [Detecting when pre-trained nnU-Net models fail silently for Covid-19 lung lesion segmentation](https://mlsanity.com/paper/2107.05975/) (2021)
- [Active learning using adaptable task-based prioritisation](https://mlsanity.com/paper/2212.01703/) (2022)
- [Panoptic segmentation with highly imbalanced semantic labels](https://mlsanity.com/paper/2203.11692/) (2022)

## Built on by (most cited first, 4 of 4)

- [PhenoBench: A Comprehensive Benchmark for Cell Phenotyping](https://mlsanity.com/paper/2507.03532/) (2025)
- [Better than Average: Spatially-Aware Aggregation of Segmentation Uncertainty Improves Downstream Performance](https://mlsanity.com/paper/2603.29941/) (2026)
- [Uncertainty-Aware Deep Learning for Genomics Applications: Insights from an Empirical Study](https://mlsanity.com/paper/2608.11054/) (2026)
- [A Multi-Annotator Study of Segmentation Noise and Uncertainty in Turbid Underwater Images](https://mlsanity.com/paper/2608.15363/) (2026)

## Abstract (arXiv)

Uncertainty Quantification (UQ) is crucial for reliable image segmentation. Yet, while the field sees continual development of novel methods, a lack of agreed-upon benchmarks limits their systematic comparison and evaluation: Current UQ methods are typically tested either on overly simplistic toy datasets or on complex real-world datasets that do not allow to discern true uncertainty. To unify both controllability and complexity, we introduce Arctique, a procedurally generated dataset modeled after histopathological colon images. We chose histopathological images for two reasons: 1) their complexity in terms of intricate object structures and highly variable appearance, which yields challenging segmentation problems, and 2) their broad prevalence for medical diagnosis and respective relevance of high-quality UQ. To generate Arctique, we established a Blender-based framework for 3D scene creation with intrinsic noise manipulation. Arctique contains 50,000 rendered images with precise masks as well as noisy label simulations. We show that by independently controlling the uncertainty in both images and labels, we can effectively study the performance of several commonly used UQ methods. Hence, Arctique serves as a critical resource for benchmarking and advancing UQ techniques and other methodologies in complex, multi-object environments, bridging the gap between realism and controllability. All code is publicly available, allowing re-creation and controlled manipulations of our shipped images as well as creation and rendering of new scenes.