# Self-supervised Representation Learning for Cell Event Recognition through Time Arrow Prediction

arXiv: https://arxiv.org/abs/2411.03924 · HTML: https://mlsanity.com/paper/2411.03924/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 21 references that are in the map.
- First posted on arXiv 6 Nov 2024.

## Builds on (most cited first, 14 of 14)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [On Calibration of Modern Neural Networks](https://mlsanity.com/paper/1706.04599/) (2017)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Cell Detection with Star-convex Polygons](https://mlsanity.com/paper/1806.03535/) (2018)
- [Self-Supervised Representation Learning: Introduction, Advances and Challenges](https://mlsanity.com/paper/2110.09327/) (2021)
- [Video Anomaly Detection by Solving Decoupled Spatio-Temporal Jigsaw Puzzles](https://mlsanity.com/paper/2207.10172/) (2022)
- [Star-convex Polyhedra for 3D Object Detection and Segmentation in Microscopy](https://mlsanity.com/paper/1908.03636/) (2019)
- [Recur, Attend or Convolve? On Whether Temporal Modeling Matters for Cross-Domain Robustness in Action Recognition](https://mlsanity.com/paper/2112.12175/) (2021)
- [Self-supervised dense representation learning for live-cell microscopy with time arrow prediction](https://mlsanity.com/paper/2305.05511/) (2023)

## Abstract (arXiv)

The spatio-temporal nature of live-cell microscopy data poses challenges in the analysis of cell states which is fundamental in bioimaging. Deep-learning based segmentation or tracking methods rely on large amount of high quality annotations to work effectively. In this work, we explore an alternative solution: using feature maps obtained from self-supervised representation learning (SSRL) on time arrow prediction (TAP) for the downstream supervised task of cell event recognition. We demonstrate through extensive experiments and analysis that this approach can achieve better performance with limited annotation compared to models trained from end to end using fully supervised approach. Our analysis also provides insight into applications of the SSRL using TAP in live-cell microscopy.