# On-Site Precise Screening of SARS-CoV-2 Systems Using a Channel-Wise Attention-Based PLS-1D-CNN Model with Limited Infrared Signatures

arXiv: https://arxiv.org/abs/2410.20132 · HTML: https://mlsanity.com/paper/2410.20132/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 58 references that are in the map.
- First posted on arXiv 26 Oct 2024.

## Builds on (most cited first, 3 of 3)

- [RCoNet: Deformable Mutual Information Maximization and High-order Uncertainty-aware Learning for Robust COVID-19 Detection](https://mlsanity.com/paper/2102.11099/) (2021)
- [COVID-19 Detection from Respiratory Sounds with Hierarchical Spectrogram Transformers](https://mlsanity.com/paper/2207.09529/) (2022)
- [Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning](https://mlsanity.com/paper/2206.02788/) (2022)

## Abstract (arXiv)

During the early stages of respiratory virus outbreaks, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the efficient utilize of limited nasopharyngeal swabs for rapid and accurate screening is crucial for public health. In this study, we present a methodology that integrates attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) with the adaptive iteratively reweighted penalized least squares (airPLS) preprocessing algorithm and a channel-wise attention-based partial least squares one-dimensional convolutional neural network (PLS-1D-CNN) model, enabling accurate screening of infected individuals within 10 minutes. Two cohorts of nasopharyngeal swab samples, comprising 126 and 112 samples from suspected SARS-CoV-2 Omicron variant cases, were collected at Beijing You'an Hospital for verification. Given that ATR-FTIR spectra are highly sensitive to variations in experimental conditions, which can affect their quality, we propose a biomolecular importance (BMI) evaluation method to assess signal quality across different conditions, validated by comparing BMI with PLS-GBM and PLS-RF results. For the ATR-FTIR signals in cohort 2, which exhibited a higher BMI, airPLS was utilized for signal preprocessing, followed by the application of the channel-wise attention-based PLS-1D-CNN model for screening. The experimental results demonstrate that our model outperforms recently reported methods in the field of respiratory virus spectrum detection, achieving a recognition screening accuracy of 96.48%, a sensitivity of 96.24%, a specificity of 97.14%, an F1-score of 96.12%, and an AUC of 0.99. It meets the World Health Organization (WHO) recommended criteria for an acceptable product: sensitivity of 95.00% or greater and specificity of 97.00% or greater for testing prior SARS-CoV-2 infection in moderate to high volume scenarios.