# Advancing Histopathology with Deep Learning Under Data Scarcity: A Decade in Review

arXiv: https://arxiv.org/abs/2410.19820 · HTML: https://mlsanity.com/paper/2410.19820/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 88 of its 198 references that are in the map.
- First posted on arXiv 18 Oct 2024.

## Builds on (most cited first, 30 of 88)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [FaceNet: A Unified Embedding for Face Recognition and Clustering](https://mlsanity.com/paper/1503.03832/) (2015)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [Quantization and Training of Neural Networks for Efficient Integer-Arithmetic-Only Inference](https://mlsanity.com/paper/1712.05877/) (2017)
- [Unsupervised Representation Learning by Predicting Image Rotations](https://mlsanity.com/paper/1803.07728/) (2018)
- [Unsupervised Learning of Visual Representations by Solving Jigsaw Puzzles](https://mlsanity.com/paper/1603.09246/) (2016)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [StarGAN: Unified Generative Adversarial Networks for Multi-Domain Image-to-Image Translation](https://mlsanity.com/paper/1711.09020/) (2017)
- [What is the State of Neural Network Pruning?](https://mlsanity.com/paper/2003.03033/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Gland Segmentation in Colon Histology Images: The GlaS Challenge Contest](https://mlsanity.com/paper/1603.00275/) (2016)
- [Gradient Magnitude Similarity Deviation: A Highly Efficient Perceptual Image Quality Index](https://mlsanity.com/paper/1308.3052/) (2013)
- [Quilt-1M: One Million Image-Text Pairs for Histopathology](https://mlsanity.com/paper/2306.11207/) (2023)
- [Not-so-supervised: a survey of semi-supervised, multi-instance, and transfer learning in medical image analysis](https://mlsanity.com/paper/1804.06353/) (2018)
- [Pathomic Fusion: An Integrated Framework for Fusing Histopathology and Genomic Features for Cancer Diagnosis and Prognosis](https://mlsanity.com/paper/1912.08937/) (2019)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification](https://mlsanity.com/paper/1504.07947/) (2015)
- [Efficient Deep Learning: A Survey on Making Deep Learning Models Smaller, Faster, and Better](https://mlsanity.com/paper/2106.08962/) (2021)
- [Suggestive Annotation: A Deep Active Learning Framework for Biomedical Image Segmentation](https://mlsanity.com/paper/1706.04737/) (2017)

## Built on by (most cited first, 1 of 1)

- [MAPLE: Multi-scale Attribute-enhanced Prompt Learning for Few-shot Whole Slide Image Classification](https://mlsanity.com/paper/2509.25863/) (2025)

## Abstract (arXiv)

Recent years witnessed remarkable progress in computational histopathology, largely fueled by deep learning. This brought the clinical adoption of deep learning-based tools within reach, promising significant benefits to healthcare, offering a valuable second opinion on diagnoses, streamlining complex tasks, and mitigating the risks of inconsistency and bias in clinical decisions. However, a well-known challenge is that deep learning models may contain up to billions of parameters; supervising their training effectively would require vast labeled datasets to achieve reliable generalization and noise resilience. In medical imaging, particularly histopathology, amassing such extensive labeled data collections places additional demands on clinicians and incurs higher costs, which hinders the art's progress. Addressing this challenge, researchers devised various strategies for leveraging deep learning with limited data and annotation availability. In this paper, we present a comprehensive review of deep learning applications in histopathology, with a focus on the challenges posed by data scarcity over the past decade. We systematically categorize and compare various approaches, evaluate their distinct contributions using benchmarking tables, and highlight their respective advantages and limitations. Additionally, we address gaps in existing reviews and identify underexplored research opportunities, underscoring the potential for future advancements in this field.