# Detection of Emerging Infectious Diseases in Lung CT based on Spatial Anomaly Patterns

arXiv: https://arxiv.org/abs/2410.19535 · HTML: https://mlsanity.com/paper/2410.19535/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 28 references that are in the map.
- First posted on arXiv 25 Oct 2024.

## Builds on (most cited first, 9 of 9)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [A Neural Algorithm of Artistic Style](https://mlsanity.com/paper/1508.06576/) (2015)
- [Fast Unsupervised Brain Anomaly Detection and Segmentation with Diffusion Models](https://mlsanity.com/paper/2206.03461/) (2022)
- [Unsupervised Brain Anomaly Detection and Segmentation with Transformers](https://mlsanity.com/paper/2102.11650/) (2021)
- [Unsupervised Identification of Disease Marker Candidates in Retinal OCT Imaging Data](https://mlsanity.com/paper/1810.13404/) (2018)
- [3D unsupervised anomaly detection and localization through virtual multi-view projection and reconstruction: Clinical validation on low-dose chest computed tomography](https://mlsanity.com/paper/2206.13385/) (2022)

## Abstract (arXiv)

Fast detection of emerging diseases is important for containing their spread and treating patients effectively. Local anomalies are relevant, but often novel diseases involve familiar disease patterns in new spatial distributions. Therefore, established local anomaly detection approaches may fail to identify them as new. Here, we present a novel approach to detect the emergence of new disease phenotypes exhibiting distinct patterns of the spatial distribution of lesions. We first identify anomalies in lung CT data, and then compare their distribution in a continually acquired new patient cohorts with historic patient population observed over a long prior period. We evaluate how accumulated evidence collected in the stream of patients is able to detect the onset of an emerging disease. In a gram-matrix based representation derived from the intermediate layers of a three-dimensional convolutional neural network, newly emerging clusters indicate emerging diseases.