# Indication Finding: a novel use case for representation learning

arXiv: https://arxiv.org/abs/2410.19174 · HTML: https://mlsanity.com/paper/2410.19174/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 49 references that are in the map.
- First posted on arXiv 24 Oct 2024.

## Builds on (most cited first, 5 of 5)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Efficient Estimation of Word Representations in Vector Space](https://mlsanity.com/paper/1301.3781/) (2013)
- [BEHRT: Transformer for Electronic Health Records](https://mlsanity.com/paper/1907.09538/) (2019)
- [The Shaky Foundations of Clinical Foundation Models: A Survey of Large Language Models and Foundation Models for EMRs](https://mlsanity.com/paper/2303.12961/) (2023)
- [KGML-xDTD: A Knowledge Graph-based Machine Learning Framework for Drug Treatment Prediction and Mechanism Description](https://mlsanity.com/paper/2212.01384/) (2022)

## Abstract (arXiv)

Many therapies are effective in treating multiple diseases. We present an approach that leverages methods developed in natural language processing and real-world data to prioritize potential, new indications for a mechanism of action (MoA). We specifically use representation learning to generate embeddings of indications and prioritize them based on their proximity to the indications with the strongest available evidence for the MoA. We demonstrate the successful deployment of our approach for anti-IL-17A using embeddings generated with SPPMI and present an evaluation framework to determine the quality of indication finding results and the derived embeddings.