# Conditioning 3D Diffusion Models with 2D Images: Towards Standardized OCT Volumes through En Face-Informed Super-Resolution

arXiv: https://arxiv.org/abs/2410.09862 · HTML: https://mlsanity.com/paper/2410.09862/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 15 of its 34 references that are in the map.
- First posted on arXiv 13 Oct 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 15 of 15)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [Generative AI for Medical Imaging: extending the MONAI Framework](https://mlsanity.com/paper/2307.15208/) (2023)
- [GAMMA Challenge:Glaucoma grAding from Multi-Modality imAges](https://mlsanity.com/paper/2202.06511/) (2022)
- [Tackling Structural Hallucination in Image Translation with Local Diffusion](https://mlsanity.com/paper/2404.05980/) (2024)
- [Autoencoding Low-Resolution MRI for Semantically Smooth Interpolation of Anisotropic MRI](https://mlsanity.com/paper/2202.09258/) (2022)
- [HRINet: Alternative Supervision Network for High-resolution CT image Interpolation](https://mlsanity.com/paper/2002.04455/) (2020)

## Built on by (most cited first, 1 of 1)

- [Deep Generative Models for Enhanced Vitreous OCT Imaging](https://mlsanity.com/paper/2511.00881/) (2025)

## Abstract (arXiv)

High anisotropy in volumetric medical images can lead to the inconsistent quantification of anatomical and pathological structures. Particularly in optical coherence tomography (OCT), slice spacing can substantially vary across and within datasets, studies, and clinical practices. We propose to standardize OCT volumes to less anisotropic volumes by conditioning 3D diffusion models with en face scanning laser ophthalmoscopy (SLO) imaging data, a 2D modality already commonly available in clinical practice. We trained and evaluated on data from the multicenter and multimodal MACUSTAR study. While upsampling the number of slices by a factor of 8, our method outperforms tricubic interpolation and diffusion models without en face conditioning in terms of perceptual similarity metrics. Qualitative results demonstrate improved coherence and structural similarity. Our approach allows for better informed generative decisions, potentially reducing hallucinations. We hope this work will provide the next step towards standardized high-quality volumetric imaging, enabling more consistent quantifications.