# MentalArena: Self-play Training of Language Models for Diagnosis and Treatment of Mental Health Disorders

arXiv: https://arxiv.org/abs/2410.06845 · HTML: https://mlsanity.com/paper/2410.06845/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical synthetic data and agents, one of 13 directions in Synthetic data and self-improvement for LLMs.
- Builds on 37 of its 57 references that are in the map.
- First posted on arXiv 9 Oct 2024.

## Placed in

- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 30 of 37)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [Challenging BIG-Bench Tasks and Whether Chain-of-Thought Can Solve Them](https://mlsanity.com/paper/2210.09261/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Mastering Chess and Shogi by Self-Play with a General Reinforcement Learning Algorithm](https://mlsanity.com/paper/1712.01815/) (2017)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [Meta-Rewarding Language Models: Self-Improving Alignment with LLM-as-a-Meta-Judge](https://mlsanity.com/paper/2407.19594/) (2024)
- [Large Language Models are Few-Shot Health Learners](https://mlsanity.com/paper/2305.15525/) (2023)
- [Large Language Models are Superpositions of All Characters: Attaining Arbitrary Role-play via Self-Alignment](https://mlsanity.com/paper/2401.12474/) (2024)
- [Systematic Biases in LLM Simulations of Debates](https://mlsanity.com/paper/2402.04049/) (2024)
- [SOTOPIA-π: Interactive Learning of Socially Intelligent Language Agents](https://mlsanity.com/paper/2403.08715/) (2024)
- [AgentGen: Enhancing Planning Abilities for Large Language Model based Agent via Environment and Task Generation](https://mlsanity.com/paper/2408.00764/) (2024)
- [Dreaddit: A Reddit Dataset for Stress Analysis in Social Media](https://mlsanity.com/paper/1911.00133/) (2019)
- [Roleplay-doh: Enabling Domain-Experts to Create LLM-simulated Patients via Eliciting and Adhering to Principles](https://mlsanity.com/paper/2407.00870/) (2024)
- [Making Large Language Models Better Reasoners with Alignment](https://mlsanity.com/paper/2309.02144/) (2023)
- [Towards Interpretable Mental Health Analysis with Large Language Models](https://mlsanity.com/paper/2304.03347/) (2023)
- [Submodularity In Machine Learning and Artificial Intelligence](https://mlsanity.com/paper/2202.00132/) (2022)
- [CAMS: An Annotated Corpus for Causal Analysis of Mental Health Issues in Social Media Posts](https://mlsanity.com/paper/2207.04674/) (2022)
- [Bootstrapping LLM-based Task-Oriented Dialogue Agents via Self-Talk](https://mlsanity.com/paper/2401.05033/) (2024)
- [I-SHEEP: Self-Alignment of LLM from Scratch through an Iterative Self-Enhancement Paradigm](https://mlsanity.com/paper/2408.08072/) (2024)
- [PsycoLLM: Enhancing LLM for Psychological Understanding and Evaluation](https://mlsanity.com/paper/2407.05721/) (2024)

## Built on by (most cited first, 1 of 1)

- [Diversity-Enhanced Reasoning for Subjective Questions](https://mlsanity.com/paper/2507.20187/) (2025)

## Abstract (arXiv)

Mental health disorders are one of the most serious diseases in the world. Most people with such a disease lack access to adequate care, which highlights the importance of training models for the diagnosis and treatment of mental health disorders. However, in the mental health domain, privacy concerns limit the accessibility of personalized treatment data, making it challenging to build powerful models. In this paper, we introduce MentalArena, a self-play framework to train language models by generating domain-specific personalized data, where we obtain a better model capable of making a personalized diagnosis and treatment (as a therapist) and providing information (as a patient). To accurately model human-like mental health patients, we devise Symptom Encoder, which simulates a real patient from both cognition and behavior perspectives. To address intent bias during patient-therapist interactions, we propose Symptom Decoder to compare diagnosed symptoms with encoded symptoms, and dynamically manage the dialogue between patient and therapist according to the identified deviations. We evaluated MentalArena against 6 benchmarks, including biomedicalQA and mental health tasks, compared to 6 advanced models. Our models, fine-tuned on both GPT-3.5 and Llama-3-8b, significantly outperform their counterparts, including GPT-4o. We hope that our work can inspire future research on personalized care. Code is available in https://github.com/Scarelette/MentalArena/tree/main