# Leveraging Multimodal Diffusion Models to Accelerate Imaging with Side Information

arXiv: https://arxiv.org/abs/2410.05143 · HTML: https://mlsanity.com/paper/2410.05143/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Inverse problems and image restoration, one of 14 directions in Diffusion models.
- Builds on 19 of its 35 references that are in the map.
- First posted on arXiv 7 Oct 2024.

## Placed in

- Diffusion models / [Inverse problems and image restoration](https://mlsanity.com/diffusion/inverse-problems-and-image-restoration/)

## Builds on (most cited first, 19 of 19)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Imagic: Text-Based Real Image Editing with Diffusion Models](https://mlsanity.com/paper/2210.09276/) (2022)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Text-to-image Diffusion Models in Generative AI: A Survey](https://mlsanity.com/paper/2303.07909/) (2023)
- [A Variational Perspective on Solving Inverse Problems with Diffusion Models](https://mlsanity.com/paper/2305.04391/) (2023)
- [Accelerating Convergence of Score-Based Diffusion Models, Provably](https://mlsanity.com/paper/2403.03852/) (2024)
- [Provably Robust Score-Based Diffusion Posterior Sampling for Plug-and-Play Image Reconstruction](https://mlsanity.com/paper/2403.17042/) (2024)
- [Conversion Between CT and MRI Images Using Diffusion and Score-Matching Models](https://mlsanity.com/paper/2209.12104/) (2022)
- [Deep Unfolded Tensor Robust PCA with Self-supervised Learning](https://mlsanity.com/paper/2212.11346/) (2022)
- [A Lightweight Transformer for Faster and Robust EBSD Data Collection](https://mlsanity.com/paper/2308.09693/) (2023)

## Built on by (most cited first, 3 of 3)

- [Cross-Modal Guidance for Fast Diffusion-Based Computed Tomography](https://mlsanity.com/paper/2603.01253/) (2026)
- [Inference-Time Search Using Side Information for Diffusion-Based Image Reconstruction](https://mlsanity.com/paper/2510.03352/) (2025)
- [Multimodal Diffusion to Mutually Enhance Polarized Light and Low Resolution EBSD Data](https://mlsanity.com/paper/2604.22212/) (2026)

## Abstract (arXiv)

Diffusion models have found phenomenal success as expressive priors for solving inverse problems, but their extension beyond natural images to more structured scientific domains remains limited. Motivated by applications in materials science, we aim to reduce the number of measurements required from an expensive imaging modality of interest, by leveraging side information from an auxiliary modality that is much cheaper to obtain. To deal with the non-differentiable and black-box nature of the forward model, we propose a framework to train a multimodal diffusion model over the joint modalities, turning inverse problems with black-box forward models into simple linear inpainting problems. Numerically, we demonstrate the feasibility of training diffusion models over materials imagery data, and show that our approach achieves superior image reconstruction by leveraging the available side information, requiring significantly less amount of data from the expensive microscopy modality.