# Real-time cardiac cine MRI -- A comparison of a diffusion probabilistic model with alternative state-of-the-art image reconstruction techniques for undersampled spiral acquisitions

arXiv: https://arxiv.org/abs/2410.04843 · HTML: https://mlsanity.com/paper/2410.04843/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 33 of its 61 references that are in the map.
- First posted on arXiv 7 Oct 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 33)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
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- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [One-step Diffusion with Distribution Matching Distillation](https://mlsanity.com/paper/2311.18828/) (2023)
- [On Distillation of Guided Diffusion Models](https://mlsanity.com/paper/2210.03142/) (2022)
- [Solving Inverse Problems in Medical Imaging with Score-Based Generative Models](https://mlsanity.com/paper/2111.08005/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [Learning a Variational Network for Reconstruction of Accelerated MRI Data](https://mlsanity.com/paper/1704.00447/) (2017)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [Come-Closer-Diffuse-Faster: Accelerating Conditional Diffusion Models for Inverse Problems through Stochastic Contraction](https://mlsanity.com/paper/2112.05146/) (2021)
- [Robust Compressed Sensing MRI with Deep Generative Priors](https://mlsanity.com/paper/2108.01368/) (2021)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [End-to-End Variational Networks for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2004.06688/) (2020)
- [Improving Sample Quality of Diffusion Models Using Self-Attention Guidance](https://mlsanity.com/paper/2210.00939/) (2022)
- [Decomposed Diffusion Sampler for Accelerating Large-Scale Inverse Problems](https://mlsanity.com/paper/2303.05754/) (2023)
- [Adaptive Diffusion Priors for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2207.05876/) (2022)
- [Deep Learning Methods for Parallel Magnetic Resonance Image Reconstruction](https://mlsanity.com/paper/1904.01112/) (2019)
- [Physics-Driven Deep Learning for Computational Magnetic Resonance Imaging](https://mlsanity.com/paper/2203.12215/) (2022)
- [Bayesian MRI Reconstruction with Joint Uncertainty Estimation using Diffusion Models](https://mlsanity.com/paper/2202.01479/) (2022)
- [Self-Supervised MRI Reconstruction with Unrolled Diffusion Models](https://mlsanity.com/paper/2306.16654/) (2023)
- [Recurrent Variational Network: A Deep Learning Inverse Problem Solver applied to the task of Accelerated MRI Reconstruction](https://mlsanity.com/paper/2111.09639/) (2021)
- [Deep learning for fast MR imaging: a review for learning reconstruction from incomplete k-space data](https://mlsanity.com/paper/2012.08931/) (2020)
- [Plug-and-Play Diffusion Distillation](https://mlsanity.com/paper/2406.01954/) (2024)
- [A Survey of Emerging Applications of Diffusion Probabilistic Models in MRI](https://mlsanity.com/paper/2311.11383/) (2023)
- [Fast Controllable Diffusion Models for Undersampled MRI Reconstruction](https://mlsanity.com/paper/2311.12078/) (2023)

## Abstract (arXiv)

ECG-gated cine imaging in breath-hold enables high-quality diagnostics in most patients, arrhythmia and inability to hold breath, however, can severely corrupt outcomes. Real-time cardiac MRI in free-breathing leverages robust and faster investigations regardless of these confounding factors. With the need for sufficient acceleration, adequate reconstruction methods, which transfer data into high quality images, are required. Undersampled spiral real-time acquisitions in free-breathing were conducted in a study with 16 healthy volunteers and 5 patients. Image reconstructions were performed using a novel score-based diffusion model, as well as a variational network and different compressed sensing approaches. The techniques were compared by means of an expert reader study, by calculating scalar metrics and difference images with respect to a segmented reference, and by a Bland-Altman analysis of cardiac functional parameters. In participants with irregular RR-cycles, spiral real-time acquisitions showed superior image quality with respect to the clinical reference standard. Reconstructions using the diffusion model, the variational network and l1-wavelets offered an overall comparable image quality, however sharpness was slightly increased by the diffusion approach. While slightly larger ejection fractions for the real-time acquisitions were exhibited with a bias of 1.6% for healthy subjects, differences in the data acquisition procedure resulted in uncertainties of 7.4%. The proposed real-time technique enables free-breathing acquisitions of spatio-temporal images with high-quality, covering the entire heart in less than one minute. Evaluation of the ejection fractions using the segmented reference can be significantly corrupted due to arrhythmias and averaging effects. Prolonged inference times of the diffusion model represent the main obstacle to overcome for clinical translation.