# Adapting Segment Anything Model to Melanoma Segmentation in Microscopy Slide Images

arXiv: https://arxiv.org/abs/2410.02207 · HTML: https://mlsanity.com/paper/2410.02207/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 32 references that are in the map.
- First posted on arXiv 3 Oct 2024.

## Builds on (most cited first, 13 of 13)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [AdaptFormer: Adapting Vision Transformers for Scalable Visual Recognition](https://mlsanity.com/paper/2205.13535/) (2022)
- [Segmentation Transformer: Object-Contextual Representations for Semantic Segmentation](https://mlsanity.com/paper/1909.11065/) (2019)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [EfficientSAM: Leveraged Masked Image Pretraining for Efficient Segment Anything](https://mlsanity.com/paper/2312.00863/) (2023)
- [Segment Anything Model (SAM) for Digital Pathology: Assess Zero-shot Segmentation on Whole Slide Imaging](https://mlsanity.com/paper/2304.04155/) (2023)
- [SAM.MD: Zero-shot medical image segmentation capabilities of the Segment Anything Model](https://mlsanity.com/paper/2304.05396/) (2023)
- [Can SAM Segment Polyps?](https://mlsanity.com/paper/2304.07583/) (2023)
- [Input Augmentation with SAM: Boosting Medical Image Segmentation with Segmentation Foundation Model](https://mlsanity.com/paper/2304.11332/) (2023)
- [HookNet: multi-resolution convolutional neural networks for semantic segmentation in histopathology whole-slide images](https://mlsanity.com/paper/2006.12230/) (2020)

## Abstract (arXiv)

Melanoma segmentation in Whole Slide Images (WSIs) is useful for prognosis and the measurement of crucial prognostic factors such as Breslow depth and primary invasive tumor size. In this paper, we present a novel approach that uses the Segment Anything Model (SAM) for automatic melanoma segmentation in microscopy slide images. Our method employs an initial semantic segmentation model to generate preliminary segmentation masks that are then used to prompt SAM. We design a dynamic prompting strategy that uses a combination of centroid and grid prompts to achieve optimal coverage of the super high-resolution slide images while maintaining the quality of generated prompts. To optimize for invasive melanoma segmentation, we further refine the prompt generation process by implementing in-situ melanoma detection and low-confidence region filtering. We select Segformer as the initial segmentation model and EfficientSAM as the segment anything model for parameter-efficient fine-tuning. Our experimental results demonstrate that this approach not only surpasses other state-of-the-art melanoma segmentation methods but also significantly outperforms the baseline Segformer by 9.1% in terms of IoU.