# Privacy-Preserving SAM Quantization for Efficient Edge Intelligence in Healthcare

arXiv: https://arxiv.org/abs/2410.01813 · HTML: https://mlsanity.com/paper/2410.01813/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 31 of its 57 references that are in the map.
- First posted on arXiv 14 Sep 2024.

## Builds on (most cited first, 30 of 31)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [A Survey of Quantization Methods for Efficient Neural Network Inference](https://mlsanity.com/paper/2103.13630/) (2021)
- [Learned Step Size Quantization](https://mlsanity.com/paper/1902.08153/) (2019)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Quantizing deep convolutional networks for efficient inference: A whitepaper](https://mlsanity.com/paper/1806.08342/) (2018)
- [HAQ: Hardware-Aware Automated Quantization with Mixed Precision](https://mlsanity.com/paper/1811.08886/) (2018)
- [Faster Segment Anything: Towards Lightweight SAM for Mobile Applications](https://mlsanity.com/paper/2306.14289/) (2023)
- [Fast Segment Anything](https://mlsanity.com/paper/2306.12156/) (2023)
- [ZeroQ: A Novel Zero Shot Quantization Framework](https://mlsanity.com/paper/2001.00281/) (2020)
- [Segment Anything in Medical Images](https://mlsanity.com/paper/2304.12306/) (2023)
- [AbdomenCT-1K: Is Abdominal Organ Segmentation A Solved Problem?](https://mlsanity.com/paper/2010.14808/) (2020)
- [Skin Lesion Analysis toward Melanoma Detection: A Challenge at the International Symposium on Biomedical Imaging (ISBI) 2016, hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1605.01397/) (2016)
- [2017 Robotic Instrument Segmentation Challenge](https://mlsanity.com/paper/1902.06426/) (2019)
- [RepQ-ViT: Scale Reparameterization for Post-Training Quantization of Vision Transformers](https://mlsanity.com/paper/2212.08254/) (2022)
- [SAM-Med2D](https://mlsanity.com/paper/2308.16184/) (2023)
- [I-ViT: Integer-only Quantization for Efficient Vision Transformer Inference](https://mlsanity.com/paper/2207.01405/) (2022)
- [Generative Low-bitwidth Data Free Quantization](https://mlsanity.com/paper/2003.03603/) (2020)
- [Annotation-efficient deep learning for automatic medical image segmentation](https://mlsanity.com/paper/2012.04885/) (2020)
- [Diversifying Sample Generation for Accurate Data-Free Quantization](https://mlsanity.com/paper/2103.01049/) (2021)
- [Patch Similarity Aware Data-Free Quantization for Vision Transformers](https://mlsanity.com/paper/2203.02250/) (2022)
- [IntraQ: Learning Synthetic Images with Intra-Class Heterogeneity for Zero-Shot Network Quantization](https://mlsanity.com/paper/2111.09136/) (2021)
- [PSAQ-ViT V2: Towards Accurate and General Data-Free Quantization for Vision Transformers](https://mlsanity.com/paper/2209.05687/) (2022)
- [PTQ4SAM: Post-Training Quantization for Segment Anything](https://mlsanity.com/paper/2405.03144/) (2024)
- [I-MedSAM: Implicit Medical Image Segmentation with Segment Anything](https://mlsanity.com/paper/2311.17081/) (2023)
- [Bi-VLGM : Bi-Level Class-Severity-Aware Vision-Language Graph Matching for Text Guided Medical Image Segmentation](https://mlsanity.com/paper/2305.12231/) (2023)

## Built on by (most cited first, 4 of 4)

- [The Rise of Small Language Models in Healthcare: A Comprehensive Survey](https://mlsanity.com/paper/2504.17119/) (2025)
- [SAQ-SAM: Semantically-Aligned Quantization for Segment Anything Model](https://mlsanity.com/paper/2503.06515/) (2025)
- [Efficient-SAM2: Accelerating SAM2 with Object-Aware Visual Encoding and Memory Retrieval](https://mlsanity.com/paper/2602.08224/) (2026)
- [Hammering the Diagnosis: Rowhammer-Induced Stealthy Trojan Attacks on ViT-Based Medical Imaging](https://mlsanity.com/paper/2510.24976/) (2025)

## Abstract (arXiv)

The disparity in healthcare personnel expertise and medical resources across different regions of the world is a pressing social issue. Artificial intelligence technology offers new opportunities to alleviate this issue. Segment Anything Model (SAM), which excels in intelligent image segmentation, has demonstrated exceptional performance in medical monitoring and assisted diagnosis. Unfortunately, the huge computational and storage overhead of SAM poses significant challenges for deployment on resource-limited edge devices. Quantization is an effective solution for model compression; however, traditional methods rely heavily on original data for calibration, which raises widespread concerns about medical data privacy and security. In this paper, we propose a data-free quantization framework for SAM, called DFQ-SAM, which learns and calibrates quantization parameters without any original data, thus effectively preserving data privacy during model compression. Specifically, we propose pseudo-positive label evolution for segmentation, combined with patch similarity, to fully leverage the semantic and distribution priors in pre-trained models, which facilitates high-quality data synthesis as a substitute for real data. Furthermore, we introduce scale reparameterization to ensure the accuracy of low-bit quantization. We perform extensive segmentation experiments on various datasets, and DFQ-SAM consistently provides significant performance on low-bit quantization. DFQ-SAM eliminates the need for data transfer in cloud-edge collaboration, thereby protecting sensitive data from potential attacks. It enables secure, fast, and personalized healthcare services at the edge, which enhances system efficiency and optimizes resource allocation, and thus facilitating the pervasive application of artificial intelligence in worldwide healthcare.