# RadGazeGen: Radiomics and Gaze-guided Medical Image Generation using Diffusion Models

arXiv: https://arxiv.org/abs/2410.00307 · HTML: https://mlsanity.com/paper/2410.00307/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 50 of its 71 references that are in the map.
- First posted on arXiv 1 Oct 2024.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 50)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [SDEdit: Guided Image Synthesis and Editing with Stochastic Differential Equations](https://mlsanity.com/paper/2108.01073/) (2021)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [GenEval: An Object-Focused Framework for Evaluating Text-to-Image Alignment](https://mlsanity.com/paper/2310.11513/) (2023)
- [Blended Diffusion for Text-driven Editing of Natural Images](https://mlsanity.com/paper/2111.14818/) (2021)
- [GLIGEN: Open-Set Grounded Text-to-Image Generation](https://mlsanity.com/paper/2301.07093/) (2023)
- [Solving Inverse Problems in Medical Imaging with Score-Based Generative Models](https://mlsanity.com/paper/2111.08005/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [Uni-ControlNet: All-in-One Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2305.16322/) (2023)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [Come-Closer-Diffuse-Faster: Accelerating Conditional Diffusion Models for Inverse Problems through Stochastic Contraction](https://mlsanity.com/paper/2112.05146/) (2021)
- [Composer: Creative and Controllable Image Synthesis with Composable Conditions](https://mlsanity.com/paper/2302.09778/) (2023)
- [Robust Compressed Sensing MRI with Deep Generative Priors](https://mlsanity.com/paper/2108.01368/) (2021)
- [MDTv2: Masked Diffusion Transformer is a Strong Image Synthesizer](https://mlsanity.com/paper/2303.14389/) (2023)
- [UniControl: A Unified Diffusion Model for Controllable Visual Generation In the Wild](https://mlsanity.com/paper/2305.11147/) (2023)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [Interactive and Explainable Region-guided Radiology Report Generation](https://mlsanity.com/paper/2304.08295/) (2023)
- [TorchXRayVision: A library of chest X-ray datasets and models](https://mlsanity.com/paper/2111.00595/) (2021)
- [Ambiguous Medical Image Segmentation using Diffusion Models](https://mlsanity.com/paper/2304.04745/) (2023)
- [Generative AI for Medical Imaging: extending the MONAI Framework](https://mlsanity.com/paper/2307.15208/) (2023)
- [Measurement-conditioned Denoising Diffusion Probabilistic Model for Under-sampled Medical Image Reconstruction](https://mlsanity.com/paper/2203.03623/) (2022)
- [Zero-shot spatial layout conditioning for text-to-image diffusion models](https://mlsanity.com/paper/2306.13754/) (2023)
- [Towards performant and reliable undersampled MR reconstruction via diffusion model sampling](https://mlsanity.com/paper/2203.04292/) (2022)

## Built on by (most cited first, 4 of 4)

- [BrainMRDiff: A Diffusion Model for Anatomically Consistent Brain MRI Synthesis](https://mlsanity.com/paper/2504.04532/) (2025)
- [ImmunoDiff: A Diffusion Model for Immunotherapy Response Prediction in Lung Cancer](https://mlsanity.com/paper/2505.23675/) (2025)
- [GazeLT: Visual attention-guided long-tailed disease classification in chest radiographs](https://mlsanity.com/paper/2508.09478/) (2025)
- [Pathologist Attention-Aligned Report Generation for Prostate Histopathology](https://mlsanity.com/paper/2607.19624/) (2026)

## Abstract (arXiv)

In this work, we present RadGazeGen, a novel framework for integrating experts' eye gaze patterns and radiomic feature maps as controls to text-to-image diffusion models for high fidelity medical image generation. Despite the recent success of text-to-image diffusion models, text descriptions are often found to be inadequate and fail to convey detailed disease-specific information to these models to generate clinically accurate images. The anatomy, disease texture patterns, and location of the disease are extremely important to generate realistic images; moreover the fidelity of image generation can have significant implications in downstream tasks involving disease diagnosis or treatment repose assessment. Hence, there is a growing need to carefully define the controls used in diffusion models for medical image generation. Eye gaze patterns of radiologists are important visuo-cognitive information, indicative of subtle disease patterns and spatial location. Radiomic features further provide important subvisual cues regarding disease phenotype. In this work, we propose to use these gaze patterns in combination with standard radiomics descriptors, as controls, to generate anatomically correct and disease-aware medical images. RadGazeGen is evaluated for image generation quality and diversity on the REFLACX dataset. To demonstrate clinical applicability, we also show classification performance on the generated images from the CheXpert test set (n=500) and long-tailed learning performance on the MIMIC-CXR-LT test set (n=23550).