# Leveraging CAM Algorithms for Explaining Medical Semantic Segmentation

arXiv: https://arxiv.org/abs/2409.20287 · HTML: https://mlsanity.com/paper/2409.20287/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 25 references that are in the map.
- First posted on arXiv 30 Sep 2024.

## Builds on (most cited first, 19 of 19)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [The Cityscapes Dataset for Semantic Urban Scene Understanding](https://mlsanity.com/paper/1604.01685/) (2016)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks](https://mlsanity.com/paper/1710.11063/) (2017)
- [Score-CAM: Score-Weighted Visual Explanations for Convolutional Neural Networks](https://mlsanity.com/paper/1910.01279/) (2019)
- [A Benchmark for Interpretability Methods in Deep Neural Networks](https://mlsanity.com/paper/1806.10758/) (2018)
- [Full-Gradient Representation for Neural Network Visualization](https://mlsanity.com/paper/1905.00780/) (2019)
- [Eigen-CAM: Class Activation Map using Principal Components](https://mlsanity.com/paper/2008.00299/) (2020)
- [Axiom-based Grad-CAM: Towards Accurate Visualization and Explanation of CNNs](https://mlsanity.com/paper/2008.02312/) (2020)
- [Use HiResCAM instead of Grad-CAM for faithful explanations of convolutional neural networks](https://mlsanity.com/paper/2011.08891/) (2020)
- [Towards Interpretable Semantic Segmentation via Gradient-weighted Class Activation Mapping](https://mlsanity.com/paper/2002.11434/) (2020)
- [Towards Better Explanations of Class Activation Mapping](https://mlsanity.com/paper/2102.05228/) (2021)
- [Towards the Unification and Robustness of Perturbation and Gradient Based Explanations](https://mlsanity.com/paper/2102.10618/) (2021)
- [Explainable Medical Imaging AI Needs Human-Centered Design: Guidelines and Evidence from a Systematic Review](https://mlsanity.com/paper/2112.12596/) (2021)

## Built on by (most cited first, 2 of 2)

- [Hidden in the Multiplicative Interaction: Uncovering Fragility in Multimodal Contrastive Learning](https://mlsanity.com/paper/2604.05834/) (2026)
- [Enhanced SegNet with Integrated Grad-CAM for Interpretable Retinal Layer Segmentation in OCT Images](https://mlsanity.com/paper/2509.07795/) (2025)

## Abstract (arXiv)

Convolutional neural networks (CNNs) achieve prevailing results in segmentation tasks nowadays and represent the state-of-the-art for image-based analysis. However, the understanding of the accurate decision-making process of a CNN is rather unknown. The research area of explainable artificial intelligence (xAI) primarily revolves around understanding and interpreting this black-box behavior. One way of interpreting a CNN is the use of class activation maps (CAMs) that represent heatmaps to indicate the importance of image areas for the prediction of the CNN. For classification tasks, a variety of CAM algorithms exist. But for segmentation tasks, only one CAM algorithm for the interpretation of the output of a CNN exist. We propose a transfer between existing classification- and segmentation-based methods for more detailed, explainable, and consistent results which show salient pixels in semantic segmentation tasks. The resulting Seg-HiRes-Grad CAM is an extension of the segmentation-based Seg-Grad CAM with the transfer to the classification-based HiRes CAM. Our method improves the previously-mentioned existing segmentation-based method by adjusting it to recently published classification-based methods. Especially for medical image segmentation, this transfer solves existing explainability disadvantages.