# A novel application of Shapley values for large multidimensional time-series data: Applying explainable AI to a DNA profile classification neural network

arXiv: https://arxiv.org/abs/2409.18156 · HTML: https://mlsanity.com/paper/2409.18156/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 15 references that are in the map.
- First posted on arXiv 26 Sep 2024.

## Builds on (most cited first, 4 of 4)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Explainable Artificial Intelligence (XAI): Concepts, Taxonomies, Opportunities and Challenges toward Responsible AI](https://mlsanity.com/paper/1910.10045/) (2019)
- [Counterfactuals and Causability in Explainable Artificial Intelligence: Theory, Algorithms, and Applications](https://mlsanity.com/paper/2103.04244/) (2021)
- [RKHS-SHAP: Shapley Values for Kernel Methods](https://mlsanity.com/paper/2110.09167/) (2021)

## Abstract (arXiv)

The application of Shapley values to high-dimensional, time-series-like data is computationally challenging - and sometimes impossible. For N inputs the problem is 2N hard. In image processing, clusters of pixels, referred to as superpixels, are used to streamline computations. This research presents an efficient solution for time-seres-like data that adapts the idea of superpixels for Shapley value computation. Motivated by a forensic DNA classification example, the method is applied to multivariate time-series-like data whose features have been classified by a convolutional neural network (CNN). In DNA processing, it is important to identify alleles from the background noise created by DNA extraction and processing. A single DNA profile has 31,200 scan points to classify, and the classification decisions must be defensible in a court of law. This means that classification is routinely performed by human readers - a monumental and time consuming process. The application of a CNN with fast computation of meaningful Shapley values provides a potential alternative to the classification. This research demonstrates the realistic, accurate and fast computation of Shapley values for this massive task