# Ctrl-GenAug: Controllable Generative Augmentation for Medical Sequence Classification

arXiv: https://arxiv.org/abs/2409.17091 · HTML: https://mlsanity.com/paper/2409.17091/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 86 of its 135 references that are in the map.
- First posted on arXiv 25 Sep 2024.

## Builds on (most cited first, 30 of 86)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Quo Vadis, Action Recognition? A New Model and the Kinetics Dataset](https://mlsanity.com/paper/1705.07750/) (2017)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [SlowFast Networks for Video Recognition](https://mlsanity.com/paper/1812.03982/) (2018)
- [VBench: Comprehensive Benchmark Suite for Video Generative Models](https://mlsanity.com/paper/2311.17982/) (2023)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [Make-A-Video: Text-to-Video Generation without Text-Video Data](https://mlsanity.com/paper/2209.14792/) (2022)
- [Is Space-Time Attention All You Need for Video Understanding?](https://mlsanity.com/paper/2102.05095/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [IP-Adapter: Text Compatible Image Prompt Adapter for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2308.06721/) (2023)
- [AnimateDiff: Animate Your Personalized Text-to-Image Diffusion Models without Specific Tuning](https://mlsanity.com/paper/2307.04725/) (2023)
- [Towards Accurate Generative Models of Video: A New Metric & Challenges](https://mlsanity.com/paper/1812.01717/) (2018)
- [A Closer Look at Spatiotemporal Convolutions for Action Recognition](https://mlsanity.com/paper/1711.11248/) (2017)
- [Video Swin Transformer](https://mlsanity.com/paper/2106.13230/) (2021)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Text2Video-Zero: Text-to-Image Diffusion Models are Zero-Shot Video Generators](https://mlsanity.com/paper/2303.13439/) (2023)
- [MViTv2: Improved Multiscale Vision Transformers for Classification and Detection](https://mlsanity.com/paper/2112.01526/) (2021)
- [FateZero: Fusing Attentions for Zero-shot Text-based Video Editing](https://mlsanity.com/paper/2303.09535/) (2023)
- [MagicVideo: Efficient Video Generation With Latent Diffusion Models](https://mlsanity.com/paper/2211.11018/) (2022)
- [VideoComposer: Compositional Video Synthesis with Motion Controllability](https://mlsanity.com/paper/2306.02018/) (2023)
- [Synthetic Data from Diffusion Models Improves ImageNet Classification](https://mlsanity.com/paper/2304.08466/) (2023)

## Built on by (most cited first, 4 of 4)

- [Semantics versus Identity: A Divide-and-Conquer Approach towards Adjustable Medical Image De-Identification](https://mlsanity.com/paper/2507.21703/) (2025)
- [Subtyping Breast Lesions via Generative Augmentation based Long-tailed Recognition in Ultrasound](https://mlsanity.com/paper/2507.22568/) (2025)
- [FrameONE: Hierarchical Motion Modeling for Universal Multi-View Echocardiographic Keyframe Detection](https://mlsanity.com/paper/2607.00748/) (2026)
- [Deep Learning-based Intelligent Diagnosis of Congenital Uterine Anomalies in 3D Ultrasound](https://mlsanity.com/paper/2609.15225/) (2026)

## Abstract (arXiv)

In the medical field, the limited availability of large-scale datasets and labor-intensive annotation processes hinder the performance of deep models. Diffusion-based generative augmentation approaches present a promising solution to this issue, having been proven effective in advancing downstream medical recognition tasks. Nevertheless, existing works lack sufficient semantic and sequential steerability for challenging video/3D sequence generation, and neglect quality control of noisy synthesized samples, resulting in unreliable synthetic databases and severely limiting the performance of downstream tasks. In this work, we present Ctrl-GenAug, a novel and general generative augmentation framework that enables highly semantic- and sequential-customized sequence synthesis and suppresses incorrectly synthesized samples, to aid medical sequence classification. Specifically, we first design a multimodal conditions-guided sequence generator for controllably synthesizing diagnosis-promotive samples. A sequential augmentation module is integrated to enhance the temporal/stereoscopic coherence of generated samples. Then, we propose a noisy synthetic data filter to suppress unreliable cases at semantic and sequential levels. Extensive experiments on 3 medical datasets, using 11 networks trained on 3 paradigms, comprehensively analyze the effectiveness and generality of Ctrl-GenAug, particularly in underrepresented high-risk populations and out-domain conditions.