# Benchmarking Domain Generalization Algorithms in Computational Pathology

arXiv: https://arxiv.org/abs/2409.17063 · HTML: https://mlsanity.com/paper/2409.17063/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 45 of its 79 references that are in the map.
- First posted on arXiv 25 Sep 2024.

## Builds on (most cited first, 30 of 45)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Invariant Risk Minimization](https://mlsanity.com/paper/1907.02893/) (2019)
- [Barlow Twins: Self-Supervised Learning via Redundancy Reduction](https://mlsanity.com/paper/2103.03230/) (2021)
- [WILDS: A Benchmark of in-the-Wild Distribution Shifts](https://mlsanity.com/paper/2012.07421/) (2020)
- [Distributionally Robust Neural Networks for Group Shifts: On the Importance of Regularization for Worst-Case Generalization](https://mlsanity.com/paper/1911.08731/) (2019)
- [Deep CORAL: Correlation Alignment for Deep Domain Adaptation](https://mlsanity.com/paper/1607.01719/) (2016)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [In Search of Lost Domain Generalization](https://mlsanity.com/paper/2007.01434/) (2020)
- [Generalizing to Unseen Domains: A Survey on Domain Generalization](https://mlsanity.com/paper/2103.03097/) (2021)
- [Learning to Generalize: Meta-Learning for Domain Generalization](https://mlsanity.com/paper/1710.03463/) (2017)
- [Out-of-Distribution Generalization via Risk Extrapolation (REx)](https://mlsanity.com/paper/2003.00688/) (2020)
- [Self-Challenging Improves Cross-Domain Generalization](https://mlsanity.com/paper/2007.02454/) (2020)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [Gradient Starvation: A Learning Proclivity in Neural Networks](https://mlsanity.com/paper/2011.09468/) (2020)
- [Invariance Principle Meets Information Bottleneck for Out-of-Distribution Generalization](https://mlsanity.com/paper/2106.06607/) (2021)
- [SelfReg: Self-supervised Contrastive Regularization for Domain Generalization](https://mlsanity.com/paper/2104.09841/) (2021)
- [Improve Unsupervised Domain Adaptation with Mixup Training](https://mlsanity.com/paper/2001.00677/) (2020)
- [Adaptive Risk Minimization: Learning to Adapt to Domain Shift](https://mlsanity.com/paper/2007.02931/) (2020)
- [Domain Generalization by Marginal Transfer Learning](https://mlsanity.com/paper/1711.07910/) (2017)
- [Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology](https://mlsanity.com/paper/1902.06543/) (2019)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [Learning explanations that are hard to vary](https://mlsanity.com/paper/2009.00329/) (2020)
- [Self-Path: Self-supervision for Classification of Pathology Images with Limited Annotations](https://mlsanity.com/paper/2008.05571/) (2020)
- [Probable Domain Generalization via Quantile Risk Minimization](https://mlsanity.com/paper/2207.09944/) (2022)
- [A Clinical Benchmark of Public Self-Supervised Pathology Foundation Models](https://mlsanity.com/paper/2407.06508/) (2024)
- [When is invariance useful in an Out-of-Distribution Generalization problem ?](https://mlsanity.com/paper/2008.01883/) (2020)
- [SAND-mask: An Enhanced Gradient Masking Strategy for the Discovery of Invariances in Domain Generalization](https://mlsanity.com/paper/2106.02266/) (2021)
- [NuClick: A Deep Learning Framework for Interactive Segmentation of Microscopy Images](https://mlsanity.com/paper/2005.14511/) (2020)

## Built on by (most cited first, 3 of 3)

- [Distilling foundation models for robust and efficient models in digital pathology](https://mlsanity.com/paper/2501.16239/) (2025)
- [The Mean is the Mirage: Entropy-Adaptive Model Merging under Heterogeneous Domain Shifts in Medical Imaging](https://mlsanity.com/paper/2602.21372/) (2026)
- [Entropy Minimization without Model Collapse: Mitigating Prediction Bias in Medical Imaging](https://mlsanity.com/paper/2606.02339/) (2026)

## Abstract (arXiv)

Deep learning models have shown immense promise in computational pathology (CPath) tasks, but their performance often suffers when applied to unseen data due to domain shifts. Addressing this requires domain generalization (DG) algorithms. However, a systematic evaluation of DG algorithms in the CPath context is lacking. This study aims to benchmark the effectiveness of 30 DG algorithms on 3 CPath tasks of varying difficulty through 7,560 cross-validation runs. We evaluate these algorithms using a unified and robust platform, incorporating modality-specific techniques and recent advances like pretrained foundation models. Our extensive cross-validation experiments provide insights into the relative performance of various DG strategies. We observe that self-supervised learning and stain augmentation consistently outperform other methods, highlighting the potential of pretrained models and data augmentation. Furthermore, we introduce a new pan-cancer tumor detection dataset (HISTOPANTUM) as a benchmark for future research. This study offers valuable guidance to researchers in selecting appropriate DG approaches for CPath tasks.