# SwiftDossier: Tailored Automatic Dossier for Drug Discovery with LLMs and Agents

arXiv: https://arxiv.org/abs/2409.15817 · HTML: https://mlsanity.com/paper/2409.15817/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 24 of its 53 references that are in the map.
- First posted on arXiv 24 Sep 2024.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 24 of 24)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [HuggingFace's Transformers: State-of-the-art Natural Language Processing](https://mlsanity.com/paper/1910.03771/) (2019)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [A Survey on Evaluation of Large Language Models](https://mlsanity.com/paper/2307.03109/) (2023)
- [HuggingGPT: Solving AI Tasks with ChatGPT and its Friends in Hugging Face](https://mlsanity.com/paper/2303.17580/) (2023)
- [Large Language Models: A Survey](https://mlsanity.com/paper/2402.06196/) (2024)
- [Editing Large Language Models: Problems, Methods, and Opportunities](https://mlsanity.com/paper/2305.13172/) (2023)
- [A Survey of Hallucination in Large Foundation Models](https://mlsanity.com/paper/2309.05922/) (2023)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Fine-Tuning or Retrieval? Comparing Knowledge Injection in LLMs](https://mlsanity.com/paper/2312.05934/) (2023)
- [LAB-Bench: Measuring Capabilities of Language Models for Biology Research](https://mlsanity.com/paper/2407.10362/) (2024)
- [A Survey of Large Language Models in Medicine: Progress, Application, and Challenge](https://mlsanity.com/paper/2311.05112/) (2023)
- [GeneGPT: Augmenting Large Language Models with Domain Tools for Improved Access to Biomedical Information](https://mlsanity.com/paper/2304.09667/) (2023)
- [A Review of Large Language Models and Autonomous Agents in Chemistry](https://mlsanity.com/paper/2407.01603/) (2024)
- [Detecting Edit Failures In Large Language Models: An Improved Specificity Benchmark](https://mlsanity.com/paper/2305.17553/) (2023)
- [DrugAssist: A Large Language Model for Molecule Optimization](https://mlsanity.com/paper/2401.10334/) (2023)
- [Ever: Mitigating Hallucination in Large Language Models through Real-Time Verification and Rectification](https://mlsanity.com/paper/2311.09114/) (2023)
- [Artificial Intelligence in Drug Discovery: Applications and Techniques](https://mlsanity.com/paper/2106.05386/) (2021)
- [Redefining "Hallucination" in LLMs: Towards a psychology-informed framework for mitigating misinformation](https://mlsanity.com/paper/2402.01769/) (2024)
- [Bioinformatics and Biomedical Informatics with ChatGPT: Year One Review](https://mlsanity.com/paper/2403.15274/) (2024)

## Built on by (most cited first, 3 of 3)

- [Towards LLM Agents for Earth Observation](https://mlsanity.com/paper/2504.12110/) (2025)
- [Can Hallucinations Help? Boosting LLMs for Drug Discovery](https://mlsanity.com/paper/2501.13824/) (2025)
- [Evaluating Agentic Bioinformatics through Function, Evidence, and Validation](https://mlsanity.com/paper/2607.27556/) (2026)

## Abstract (arXiv)

The advancement of artificial intelligence algorithms has expanded their application to several fields such as the biomedical domain. Artificial intelligence systems, including Large Language Models (LLMs), can be particularly advantageous in drug discovery, which is a very long and expensive process. However, LLMs by themselves lack in-depth knowledge about specific domains and can generate factually incorrect information. Moreover, they are not able to perform more complex actions that imply the usage of external tools. Our work is focused on these two issues. Firstly, we show how the implementation of an advanced RAG system can help the LLM to generate more accurate answers to drug-discovery-related questions. The results show that the answers generated by the LLM with the RAG system surpass in quality the answers produced by the model without RAG. Secondly, we show how to create an automatic target dossier using LLMs and incorporating them with external tools that they can use to execute more intricate tasks to gather data such as accessing databases and executing code. The result is a production-ready target dossier containing the acquired information summarized into a PDF and a PowerPoint presentation.