# ManiNeg: Manifestation-guided Multimodal Pretraining for Mammography Classification

arXiv: https://arxiv.org/abs/2409.15745 · HTML: https://mlsanity.com/paper/2409.15745/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 29 of its 37 references that are in the map.
- First posted on arXiv 24 Sep 2024.

## Builds on (most cited first, 29 of 29)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generation](https://mlsanity.com/paper/2201.12086/) (2022)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [Align before Fuse: Vision and Language Representation Learning with Momentum Distillation](https://mlsanity.com/paper/2107.07651/) (2021)
- [Understanding Contrastive Representation Learning through Alignment and Uniformity on the Hypersphere](https://mlsanity.com/paper/2005.10242/) (2020)
- [ViLT: Vision-and-Language Transformer Without Convolution or Region Supervision](https://mlsanity.com/paper/2102.03334/) (2021)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [PaLI: A Jointly-Scaled Multilingual Language-Image Model](https://mlsanity.com/paper/2209.06794/) (2022)
- [Contrastive Learning with Hard Negative Samples](https://mlsanity.com/paper/2010.04592/) (2020)
- [VLMo: Unified Vision-Language Pre-Training with Mixture-of-Modality-Experts](https://mlsanity.com/paper/2111.02358/) (2021)
- [Hard Negative Mixing for Contrastive Learning](https://mlsanity.com/paper/2010.01028/) (2020)
- [Filtering, Distillation, and Hard Negatives for Vision-Language Pre-Training](https://mlsanity.com/paper/2301.02280/) (2023)
- [Generalized Radiograph Representation Learning via Cross-supervision between Images and Free-text Radiology Reports](https://mlsanity.com/paper/2111.03452/) (2021)
- [Best of Both Worlds: Multimodal Contrastive Learning with Tabular and Imaging Data](https://mlsanity.com/paper/2303.14080/) (2023)
- [Conditional Negative Sampling for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2010.02037/) (2020)
- [Robust Contrastive Learning Using Negative Samples with Diminished Semantics](https://mlsanity.com/paper/2110.14189/) (2021)
- [Exploring the Impact of Negative Samples of Contrastive Learning: A Case Study of Sentence Embedding](https://mlsanity.com/paper/2202.13093/) (2022)
- [Act Like a Radiologist: Towards Reliable Multi-view Correspondence Reasoning for Mammogram Mass Detection](https://mlsanity.com/paper/2105.10160/) (2021)
- [Hard Negative Sampling Strategies for Contrastive Representation Learning](https://mlsanity.com/paper/2206.01197/) (2022)
- [Semantically-Conditioned Negative Samples for Efficient Contrastive Learning](https://mlsanity.com/paper/2102.06603/) (2021)

## Abstract (arXiv)

Breast cancer is a significant threat to human health. Contrastive learning has emerged as an effective method to extract critical lesion features from mammograms, thereby offering a potent tool for breast cancer screening and analysis. A crucial aspect of contrastive learning involves negative sampling, where the selection of appropriate hard negative samples is essential for driving representations to retain detailed information about lesions. In contrastive learning, it is often assumed that features can sufficiently capture semantic content, and that each minibatch inherently includes ideal hard negative samples. However, the characteristics of breast lumps challenge these assumptions. In response, we introduce ManiNeg, a novel approach that leverages manifestations as proxies to mine hard negative samples. Manifestations, which refer to the observable symptoms or signs of a disease, provide a knowledge-driven and robust basis for choosing hard negative samples. This approach benefits from its invariance to model optimization, facilitating efficient sampling. To support ManiNeg and future research endeavors, we developed the MVKL dataset, which includes multi-view mammograms, corresponding reports, meticulously annotated manifestations, and pathologically confirmed benign-malignant outcomes. We evaluate ManiNeg on the benign and malignant classification task. Our results demonstrate that ManiNeg not only improves representation in both unimodal and multimodal contexts but also shows generalization across datasets. The MVKL dataset and our codes are publicly available at https://github.com/wxwxwwxxx/ManiNeg.