# A Preliminary Study of o1 in Medicine: Are We Closer to an AI Doctor?

arXiv: https://arxiv.org/abs/2409.15277 · HTML: https://mlsanity.com/paper/2409.15277/

## Key facts

- Cited by 33 papers in the map (data through 14 Oct 2026).
- Builds on 41 of its 64 references that are in the map.
- First posted on arXiv 23 Sep 2024.

## Builds on (most cited first, 30 of 41)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Llama 2: Open Foundation and Fine-Tuned Chat Models](https://mlsanity.com/paper/2307.09288/) (2023)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [Sparks of Artificial General Intelligence: Early experiments with GPT-4](https://mlsanity.com/paper/2303.12712/) (2023)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [MAUVE: Measuring the Gap Between Neural Text and Human Text using Divergence Frontiers](https://mlsanity.com/paper/2102.01454/) (2021)
- [Self-critiquing models for assisting human evaluators](https://mlsanity.com/paper/2206.05802/) (2022)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [Towards Revealing the Mystery behind Chain of Thought: A Theoretical Perspective](https://mlsanity.com/paper/2305.15408/) (2023)
- [AlignScore: Evaluating Factual Consistency with a Unified Alignment Function](https://mlsanity.com/paper/2305.16739/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [To CoT or not to CoT? Chain-of-thought helps mainly on math and symbolic reasoning](https://mlsanity.com/paper/2409.12183/) (2024)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [Explainable Automated Fact-Checking for Public Health Claims](https://mlsanity.com/paper/2010.09926/) (2020)
- [Aya Dataset: An Open-Access Collection for Multilingual Instruction Tuning](https://mlsanity.com/paper/2402.06619/) (2024)
- [HuaTuo: Tuning LLaMA Model with Chinese Medical Knowledge](https://mlsanity.com/paper/2304.06975/) (2023)
- [Eagle and Finch: RWKV with Matrix-Valued States and Dynamic Recurrence](https://mlsanity.com/paper/2404.05892/) (2024)
- [Lessons from Natural Language Inference in the Clinical Domain](https://mlsanity.com/paper/1808.06752/) (2018)
- [Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions](https://mlsanity.com/paper/2402.18060/) (2024)

## Built on by (most cited first, 30 of 33)

- [HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs](https://mlsanity.com/paper/2412.18925/) (2024)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs](https://mlsanity.com/paper/2504.00993/) (2025)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [STAR-1: Safer Alignment of Reasoning LLMs with 1K Data](https://mlsanity.com/paper/2504.01903/) (2025)
- [m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models](https://mlsanity.com/paper/2504.00869/) (2025)
- [Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL](https://mlsanity.com/paper/2505.17952/) (2025)
- [MedFrameQA: A Multi-Image Medical VQA Benchmark for Clinical Reasoning](https://mlsanity.com/paper/2505.16964/) (2025)
- [Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases](https://mlsanity.com/paper/2503.04691/) (2025)
- [Superhuman performance of a large language model on the reasoning tasks of a physician](https://mlsanity.com/paper/2412.10849/) (2024)
- [MedVLThinker: Simple Baselines for Multimodal Medical Reasoning](https://mlsanity.com/paper/2508.02669/) (2025)
- [DiffKV: Differentiated Memory Management for Large Language Models with Parallel KV Compaction](https://mlsanity.com/paper/2412.03131/) (2024)
- [ALFA: Aligning LLMs to Ask Good Questions A Case Study in Clinical Reasoning](https://mlsanity.com/paper/2502.14860/) (2025)
- [MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision](https://mlsanity.com/paper/2501.12051/) (2025)
- [Citrus: Leveraging Expert Cognitive Pathways in a Medical Language Model for Advanced Medical Decision Support](https://mlsanity.com/paper/2502.18274/) (2025)
- [MedMO: Grounding and Understanding Multimodal Large Language Model for Medical Images](https://mlsanity.com/paper/2602.06965/) (2026)
- [Knowledge or Reasoning? A Close Look at How LLMs Think Across Domains](https://mlsanity.com/paper/2506.02126/) (2025)
- [Exploring the Inquiry-Diagnosis Relationship with Advanced Patient Simulators](https://mlsanity.com/paper/2501.09484/) (2025)
- [OpenAI-o1 AB Testing: Does the o1 model really do good reasoning in math problem solving?](https://mlsanity.com/paper/2411.06198/) (2024)
- [Stabilizing Reasoning in Medical LLMs with Continued Pretraining and Reasoning Preference Optimization](https://mlsanity.com/paper/2504.18080/) (2025)
- [Knowledge Graph Augmented Large Language Models for Disease Prediction](https://mlsanity.com/paper/2512.01210/) (2025)
- [MoL for LLMs: Dual-Loss Optimization to Enhance Domain Expertise While Preserving General Capabilities](https://mlsanity.com/paper/2505.12043/) (2025)
- [Scalable Stewardship of an LLM-Assisted Clinical Benchmark with Physician Oversight](https://mlsanity.com/paper/2512.19691/) (2025)
- [Med-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning](https://mlsanity.com/paper/2601.08267/) (2026)
- [When Reasoning Hurts: Source-Aware Evaluation of Frontier LLMs for Clinical SOAP Note Generation](https://mlsanity.com/paper/2605.24902/) (2026)
- [RetSTA: An LLM-Based Approach for Standardizing Clinical Fundus Image Reports](https://mlsanity.com/paper/2503.09358/) (2025)
- [QM-ToT: A Medical Tree of Thoughts Reasoning Framework for Quantized Model](https://mlsanity.com/paper/2504.12334/) (2025)
- [Enhancing Clinical Multiple-Choice Questions Benchmarks with Knowledge Graph Guided Distractor Generation](https://mlsanity.com/paper/2506.00612/) (2025)
- [H-DDx: A Hierarchical Evaluation Framework for Differential Diagnosis](https://mlsanity.com/paper/2510.03700/) (2025)
- [Expertise Is What We Want](https://mlsanity.com/paper/2502.20335/) (2025)

## Abstract (arXiv)

Large language models (LLMs) have exhibited remarkable capabilities across various domains and tasks, pushing the boundaries of our knowledge in learning and cognition. The latest model, OpenAI's o1, stands out as the first LLM with an internalized chain-of-thought technique using reinforcement learning strategies. While it has demonstrated surprisingly strong capabilities on various general language tasks, its performance in specialized fields such as medicine remains unknown. To this end, this report provides a comprehensive exploration of o1 on different medical scenarios, examining 3 key aspects: understanding, reasoning, and multilinguality. Specifically, our evaluation encompasses 6 tasks using data from 37 medical datasets, including two newly constructed and more challenging question-answering (QA) tasks based on professional medical quizzes from the New England Journal of Medicine (NEJM) and The Lancet. These datasets offer greater clinical relevance compared to standard medical QA benchmarks such as MedQA, translating more effectively into real-world clinical utility. Our analysis of o1 suggests that the enhanced reasoning ability of LLMs may (significantly) benefit their capability to understand various medical instructions and reason through complex clinical scenarios. Notably, o1 surpasses the previous GPT-4 in accuracy by an average of 6.2% and 6.6% across 19 datasets and two newly created complex QA scenarios. But meanwhile, we identify several weaknesses in both the model capability and the existing evaluation protocols, including hallucination, inconsistent multilingual ability, and discrepant metrics for evaluation. We release our raw data and model outputs at https://ucsc-vlaa.github.io/o1_medicine/ for future research.