# GAInS: Gradient Anomaly-aware Biomedical Instance Segmentation

arXiv: https://arxiv.org/abs/2409.13988 · HTML: https://mlsanity.com/paper/2409.13988/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 30 references that are in the map.
- First posted on arXiv 21 Sep 2024.

## Builds on (most cited first, 16 of 16)

- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Cascade R-CNN: Delving into High Quality Object Detection](https://mlsanity.com/paper/1712.00726/) (2017)
- [Image Segmentation Using Deep Learning: A Survey](https://mlsanity.com/paper/2001.05566/) (2020)
- [Hybrid Task Cascade for Instance Segmentation](https://mlsanity.com/paper/1901.07518/) (2019)
- [PointRend: Image Segmentation as Rendering](https://mlsanity.com/paper/1912.08193/) (2019)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Conditional Convolutions for Instance Segmentation](https://mlsanity.com/paper/2003.05664/) (2020)
- [Mask Scoring R-CNN](https://mlsanity.com/paper/1903.00241/) (2019)
- [Learning to See the Invisible: End-to-End Trainable Amodal Instance Segmentation](https://mlsanity.com/paper/1804.08864/) (2018)
- [Prime Sample Attention in Object Detection](https://mlsanity.com/paper/1904.04821/) (2019)
- [FastInst: A Simple Query-Based Model for Real-Time Instance Segmentation](https://mlsanity.com/paper/2303.08594/) (2023)
- [MedShapeNet -- A Large-Scale Dataset of 3D Medical Shapes for Computer Vision](https://mlsanity.com/paper/2308.16139/) (2023)
- [Deep Semi-supervised Knowledge Distillation for Overlapping Cervical Cell Instance Segmentation](https://mlsanity.com/paper/2007.10787/) (2020)
- [Deep Learning for Computational Cytology: A Survey](https://mlsanity.com/paper/2202.05126/) (2022)
- [DoNet: Deep De-overlapping Network for Cytology Instance Segmentation](https://mlsanity.com/paper/2303.14373/) (2023)
- [IRNet: Instance Relation Network for Overlapping Cervical Cell Segmentation](https://mlsanity.com/paper/1908.06623/) (2019)

## Built on by (most cited first, 2 of 2)

- [Boosting Overlapping Organoid Instance Segmentation Using Pseudo-Label Unmixing and Synthesis-Assisted Learning](https://mlsanity.com/paper/2601.06642/) (2026)
- [QCell: Recombining and Aligning Cell Queries for Overlapping Instance Segmentation](https://mlsanity.com/paper/2608.29253/) (2026)

## Abstract (arXiv)

Instance segmentation plays a vital role in the morphological quantification of biomedical entities such as tissues and cells, enabling precise identification and delineation of different structures. Current methods often address the challenges of touching, overlapping or crossing instances through individual modeling, while neglecting the intrinsic interrelation between these conditions. In this work, we propose a Gradient Anomaly-aware Biomedical Instance Segmentation approach (GAInS), which leverages instance gradient information to perceive local gradient anomaly regions, thus modeling the spatial relationship between instances and refining local region segmentation. Specifically, GAInS is firstly built on a Gradient Anomaly Mapping Module (GAMM), which encodes the radial fields of instances through window sliding to obtain instance gradient anomaly maps. To efficiently refine boundaries and regions with gradient anomaly attention, we propose an Adaptive Local Refinement Module (ALRM) with a gradient anomaly-aware loss function. Extensive comparisons and ablation experiments in three biomedical scenarios demonstrate that our proposed GAInS outperforms other state-of-the-art (SOTA) instance segmentation methods. The code is available at https://github.com/DeepGAInS/GAInS.