# Efficient Classification of Histopathology Images

arXiv: https://arxiv.org/abs/2409.13720 · HTML: https://mlsanity.com/paper/2409.13720/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 41 references that are in the map.
- First posted on arXiv 8 Sep 2024.

## Builds on (most cited first, 23 of 23)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Class-Balanced Loss Based on Effective Number of Samples](https://mlsanity.com/paper/1901.05555/) (2019)
- [Learning Imbalanced Datasets with Label-Distribution-Aware Margin Loss](https://mlsanity.com/paper/1906.07413/) (2019)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Learning to Reweight Examples for Robust Deep Learning](https://mlsanity.com/paper/1803.09050/) (2018)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [A systematic study of the class imbalance problem in convolutional neural networks](https://mlsanity.com/paper/1710.05381/) (2017)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Equalization Loss for Long-Tailed Object Recognition](https://mlsanity.com/paper/2003.05176/) (2020)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Cost Sensitive Learning of Deep Feature Representations from Imbalanced Data](https://mlsanity.com/paper/1508.03422/) (2015)
- [Feature Space Augmentation for Long-Tailed Data](https://mlsanity.com/paper/2008.03673/) (2020)
- [M2m: Imbalanced Classification via Major-to-minor Translation](https://mlsanity.com/paper/2004.00431/) (2020)
- [Contrastive Learning based Hybrid Networks for Long-Tailed Image Classification](https://mlsanity.com/paper/2103.14267/) (2021)
- [Relay Backpropagation for Effective Learning of Deep Convolutional Neural Networks](https://mlsanity.com/paper/1512.05830/) (2015)
- [Generative Adversarial Minority Oversampling](https://mlsanity.com/paper/1903.09730/) (2019)
- [Cluster-to-Conquer: A Framework for End-to-End Multi-Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2103.10626/) (2021)
- [Deep Imbalanced Attribute Classification using Visual Attention Aggregation](https://mlsanity.com/paper/1807.03903/) (2018)
- [Bi-directional Weakly Supervised Knowledge Distillation for Whole Slide Image Classification](https://mlsanity.com/paper/2210.03664/) (2022)
- [DGMIL: Distribution Guided Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2206.08861/) (2022)
- [Survey of resampling techniques for improving classification performance in unbalanced datasets](https://mlsanity.com/paper/1608.06048/) (2016)
- [Efficient Classification of Very Large Images with Tiny Objects](https://mlsanity.com/paper/2106.02694/) (2021)
- [Needles in Haystacks: On Classifying Tiny Objects in Large Images](https://mlsanity.com/paper/1908.06037/) (2019)

## Abstract (arXiv)

This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of tumor patches and a set of benign patches in a cancerous slide. Due to the variable nature of region of interest the tumor positive regions may refer to an extreme minority of the pixels. This creates an important problem during patch-level classification, where the majority of patches from an image labeled as 'cancerous' are actually tumor-free. This problem is different from semantic segmentation which associates a label to every pixel in an image, because after patch extraction we are only dealing with patch-level labels.Most existing approaches address the data imbalance issue by mitigating the data shortage in minority classes in order to prevent the model from being dominated by the majority classes. These methods include data re-sampling, loss re-weighting, margin modification, and data augmentation. In this work, we mitigate the patch-level class imbalance problem by taking a divide-and-conquer approach. First, we partition the data into sub-groups, and define three separate classification sub-problems based on these data partitions. Then, using an information-theoretic cluster-based sampling of deep image patch features, we sample discriminative patches from the sub-groups. Using these sampled patches, we build corresponding deep models to solve the new classification sub-problems. Finally, we integrate information learned from the respective models to make a final decision on the patches. Our result shows that the proposed approach can perform competitively using a very low percentage of the available patches in a given whole-slide image.