# EFCM: Efficient Fine-tuning on Compressed Models for deployment of large models in medical image analysis

arXiv: https://arxiv.org/abs/2409.11817 · HTML: https://mlsanity.com/paper/2409.11817/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Distillation for medical imaging, one of 12 directions in Knowledge distillation.
- Builds on 38 of its 63 references that are in the map.
- First posted on arXiv 18 Sep 2024.

## Placed in

- Knowledge distillation / [Distillation for medical imaging](https://mlsanity.com/distill/distillation-for-medical-imaging/)

## Builds on (most cited first, 30 of 38)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Knowledge Distillation: A Survey](https://mlsanity.com/paper/2006.05525/) (2020)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Fine-Tuning can Distort Pretrained Features and Underperform Out-of-Distribution](https://mlsanity.com/paper/2202.10054/) (2022)
- [AdaptFormer: Adapting Vision Transformers for Scalable Visual Recognition](https://mlsanity.com/paper/2205.13535/) (2022)
- [MaxViT: Multi-Axis Vision Transformer](https://mlsanity.com/paper/2204.01697/) (2022)
- [Selective Kernel Networks](https://mlsanity.com/paper/1903.06586/) (2019)
- [Early Convolutions Help Transformers See Better](https://mlsanity.com/paper/2106.14881/) (2021)
- [EVA-02: A Visual Representation for Neon Genesis](https://mlsanity.com/paper/2303.11331/) (2023)
- [Distilling Knowledge via Knowledge Review](https://mlsanity.com/paper/2104.09044/) (2021)
- [Knowledge Distillation from A Stronger Teacher](https://mlsanity.com/paper/2205.10536/) (2022)
- [Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Data](https://mlsanity.com/paper/2308.02463/) (2023)
- [CrossFormer: A Versatile Vision Transformer Hinging on Cross-scale Attention](https://mlsanity.com/paper/2108.00154/) (2021)
- [On the Challenges and Perspectives of Foundation Models for Medical Image Analysis](https://mlsanity.com/paper/2306.05705/) (2023)
- [Virchow: A Million-Slide Digital Pathology Foundation Model](https://mlsanity.com/paper/2309.07778/) (2023)
- [A graph-transformer for whole slide image classification](https://mlsanity.com/paper/2205.09671/) (2022)
- [Advancing Radiograph Representation Learning with Masked Record Modeling](https://mlsanity.com/paper/2301.13155/) (2023)
- [Task-specific Fine-tuning via Variational Information Bottleneck for Weakly-supervised Pathology Whole Slide Image Classification](https://mlsanity.com/paper/2303.08446/) (2023)

## Abstract (arXiv)

The recent development of deep learning large models in medicine shows remarkable performance in medical image analysis and diagnosis, but their large number of parameters causes memory and inference latency challenges. Knowledge distillation offers a solution, but the slide-level gradients cannot be backpropagated for student model updates due to high-resolution pathological images and slide-level labels. This study presents an Efficient Fine-tuning on Compressed Models (EFCM) framework with two stages: unsupervised feature distillation and fine-tuning. In the distillation stage, Feature Projection Distillation (FPD) is proposed with a TransScan module for adaptive receptive field adjustment to enhance the knowledge absorption capability of the student model. In the slide-level fine-tuning stage, three strategies (Reuse CLAM, Retrain CLAM, and End2end Train CLAM (ETC)) are compared. Experiments are conducted on 11 downstream datasets related to three large medical models: RETFound for retina, MRM for chest X-ray, and BROW for histopathology. The experimental results demonstrate that the EFCM framework significantly improves accuracy and efficiency in handling slide-level pathological image problems, effectively addressing the challenges of deploying large medical models. Specifically, it achieves a 4.33% increase in ACC and a 5.2% increase in AUC compared to the large model BROW on the TCGA-NSCLC and TCGA-BRCA datasets. The analysis of model inference efficiency highlights the high efficiency of the distillation fine-tuning method.