# A Hybrid Multi-Factor Network with Dynamic Sequence Modeling for Early Warning of Intraoperative Hypotension

arXiv: https://arxiv.org/abs/2409.11064 · HTML: https://mlsanity.com/paper/2409.11064/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 18 of its 49 references that are in the map.
- First posted on arXiv 17 Sep 2024.

## Builds on (most cited first, 18 of 18)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Informer: Beyond Efficient Transformer for Long Sequence Time-Series Forecasting](https://mlsanity.com/paper/2012.07436/) (2020)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [Autoformer: Decomposition Transformers with Auto-Correlation for Long-Term Series Forecasting](https://mlsanity.com/paper/2106.13008/) (2021)
- [Are Transformers Effective for Time Series Forecasting?](https://mlsanity.com/paper/2205.13504/) (2022)
- [FEDformer: Frequency Enhanced Decomposed Transformer for Long-term Series Forecasting](https://mlsanity.com/paper/2201.12740/) (2022)
- [iTransformer: Inverted Transformers Are Effective for Time Series Forecasting](https://mlsanity.com/paper/2310.06625/) (2023)
- [Time-LLM: Time Series Forecasting by Reprogramming Large Language Models](https://mlsanity.com/paper/2310.01728/) (2023)
- [One Fits All:Power General Time Series Analysis by Pretrained LM](https://mlsanity.com/paper/2302.11939/) (2023)
- [CSDI: Conditional Score-based Diffusion Models for Probabilistic Time Series Imputation](https://mlsanity.com/paper/2107.03502/) (2021)
- [Gate-Variants of Gated Recurrent Unit (GRU) Neural Networks](https://mlsanity.com/paper/1701.05923/) (2017)
- [AutoFormer: Searching Transformers for Visual Recognition](https://mlsanity.com/paper/2107.00651/) (2021)
- [TSMixer: Lightweight MLP-Mixer Model for Multivariate Time Series Forecasting](https://mlsanity.com/paper/2306.09364/) (2023)
- [The Capacity and Robustness Trade-off: Revisiting the Channel Independent Strategy for Multivariate Time Series Forecasting](https://mlsanity.com/paper/2304.05206/) (2023)
- [TimeMAE: Self-Supervised Representations of Time Series with Decoupled Masked Autoencoders](https://mlsanity.com/paper/2303.00320/) (2023)
- [ConvTimeNet: A Deep Hierarchical Fully Convolutional Model for Multivariate Time Series Analysis](https://mlsanity.com/paper/2403.01493/) (2024)
- [Generative Pretrained Hierarchical Transformer for Time Series Forecasting](https://mlsanity.com/paper/2402.16516/) (2024)
- [ShapeWordNet: An Interpretable Shapelet Neural Network for Physiological Signal Classification](https://mlsanity.com/paper/2302.05021/) (2023)

## Abstract (arXiv)

Intraoperative hypotension (IOH) prediction using past physiological signals is crucial, as IOH may lead to inadequate organ perfusion and significantly elevate the risk of severe complications and mortality. However, current methods often rely on static modeling, overlooking the complex temporal dependencies and the inherently non-stationary nature of physiological signals. We propose a Hybrid Multi-Factor (HMF) network that formulates IOH prediction as a dynamic sequence forecasting task, explicitly capturing both temporal dependencies and physiological non-stationarity. We represent signal dynamics as multivariate time series and decompose them into trend and seasonal components, enabling separate modeling of long-term and periodic variations. Each component is encoded with a patch-based Transformer to balance computational efficiency and feature representation. To address distributional drift from evolving signals, we introduce a symmetric normalization mechanism. Experiments on both public and real-world clinical datasets show that HMF significantly outperforms competitive baselines. We hope HMF offers new insights into IOH prediction and ultimately promotes safer surgical care. Our code is available at https://github.com/Mingyue-Cheng/HMF.