# Learning Brain Tumor Representation in 3D High-Resolution MR Images via Interpretable State Space Models

arXiv: https://arxiv.org/abs/2409.07746 · HTML: https://mlsanity.com/paper/2409.07746/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 31 of its 55 references that are in the map.
- First posted on arXiv 12 Sep 2024.

## Builds on (most cited first, 30 of 31)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness](https://mlsanity.com/paper/2205.14135/) (2022)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [Unsupervised Feature Learning via Non-Parametric Instance-level Discrimination](https://mlsanity.com/paper/1805.01978/) (2018)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [Context Encoders: Feature Learning by Inpainting](https://mlsanity.com/paper/1604.07379/) (2016)
- [Unsupervised Learning of Visual Representations by Solving Jigsaw Puzzles](https://mlsanity.com/paper/1603.09246/) (2016)
- [Transformers are SSMs: Generalized Models and Efficient Algorithms Through Structured State Space Duality](https://mlsanity.com/paper/2405.21060/) (2024)
- [Colorful Image Colorization](https://mlsanity.com/paper/1603.08511/) (2016)
- [Unsupervised Visual Representation Learning by Context Prediction](https://mlsanity.com/paper/1505.05192/) (2015)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [Simplified State Space Layers for Sequence Modeling](https://mlsanity.com/paper/2208.04933/) (2022)
- [Combining Recurrent, Convolutional, and Continuous-time Models with Linear State-Space Layers](https://mlsanity.com/paper/2110.13985/) (2021)
- [HiPPO: Recurrent Memory with Optimal Polynomial Projections](https://mlsanity.com/paper/2008.07669/) (2020)
- [Hungry Hungry Hippos: Towards Language Modeling with State Space Models](https://mlsanity.com/paper/2212.14052/) (2022)
- [On the Parameterization and Initialization of Diagonal State Space Models](https://mlsanity.com/paper/2206.11893/) (2022)
- [Diagonal State Spaces are as Effective as Structured State Spaces](https://mlsanity.com/paper/2203.14343/) (2022)
- [Long Range Language Modeling via Gated State Spaces](https://mlsanity.com/paper/2206.13947/) (2022)
- [Mega: Moving Average Equipped Gated Attention](https://mlsanity.com/paper/2209.10655/) (2022)
- [Learning Features by Watching Objects Move](https://mlsanity.com/paper/1612.06370/) (2016)
- [Liquid Structural State-Space Models](https://mlsanity.com/paper/2209.12951/) (2022)
- [ZigMa: A DiT-style Zigzag Mamba Diffusion Model](https://mlsanity.com/paper/2403.13802/) (2024)

## Abstract (arXiv)

Learning meaningful and interpretable representations from high-dimensional volumetric magnetic resonance (MR) images is essential for advancing personalized medicine. While Vision Transformers (ViTs) have shown promise in handling image data, their application to 3D multi-contrast MR images faces challenges due to computational complexity and interpretability. To address this, we propose a novel state-space-model (SSM)-based masked autoencoder which scales ViT-like models to handle high-resolution data effectively while also enhancing the interpretability of learned representations. We propose a latent-to-spatial mapping technique that enables direct visualization of how latent features correspond to specific regions in the input volumes in the context of SSM. We validate our method on two key neuro-oncology tasks: identification of isocitrate dehydrogenase mutation status and 1p/19q co-deletion classification, achieving state-of-the-art accuracy. Our results highlight the potential of SSM-based self-supervised learning to transform radiomics analysis by combining efficiency and interpretability.