# Quantifying Knee Cartilage Shape and Lesion: From Image to Metrics

arXiv: https://arxiv.org/abs/2409.07361 · HTML: https://mlsanity.com/paper/2409.07361/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 26 references that are in the map.
- First posted on arXiv 11 Sep 2024.

## Builds on (most cited first, 10 of 10)

- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [Large Deformation Diffeomorphic Image Registration with Laplacian Pyramid Networks](https://mlsanity.com/paper/2006.16148/) (2020)
- [Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learning](https://mlsanity.com/paper/2112.04489/) (2021)
- [DeepAtlas: Joint Semi-Supervised Learning of Image Registration and Segmentation](https://mlsanity.com/paper/1904.08465/) (2019)
- [Networks for Joint Affine and Non-parametric Image Registration](https://mlsanity.com/paper/1903.08811/) (2019)
- [iSegFormer: Interactive Segmentation via Transformers with Application to 3D Knee MR Images](https://mlsanity.com/paper/2112.11325/) (2021)
- [Aladdin: Joint Atlas Building and Diffeomorphic Registration Learning with Pairwise Alignment](https://mlsanity.com/paper/2202.03563/) (2022)
- [CartiMorph: a framework for automated knee articular cartilage morphometrics](https://mlsanity.com/paper/2308.01981/) (2023)
- [Position-prior Clustering-based Self-attention Module for Knee Cartilage Segmentation](https://mlsanity.com/paper/2206.10286/) (2022)

## Built on by (most cited first, 1 of 1)

- [MedVision: Benchmarking Quantitative Medical Image Analysis](https://mlsanity.com/paper/2511.18676/) (2025)

## Abstract (arXiv)

Imaging features of knee articular cartilage have been shown to be potential imaging biomarkers for knee osteoarthritis. Despite recent methodological advancements in image analysis techniques like image segmentation, registration, and domain-specific image computing algorithms, only a few works focus on building fully automated pipelines for imaging feature extraction. In this study, we developed a deep-learning-based medical image analysis application for knee cartilage morphometrics, CartiMorph Toolbox (CMT). We proposed a 2-stage joint template learning and registration network, CMT-reg. We trained the model using the OAI-ZIB dataset and assessed its performance in template-to-image registration. The CMT-reg demonstrated competitive results compared to other state-of-the-art models. We integrated the proposed model into an automated pipeline for the quantification of cartilage shape and lesion (full-thickness cartilage loss, specifically). The toolbox provides a comprehensive, user-friendly solution for medical image analysis and data visualization. The software and models are available at https://github.com/YongchengYAO/CMT-AMAI24paper .