# Rx Strategist: Prescription Verification using LLM Agents System

arXiv: https://arxiv.org/abs/2409.03440 · HTML: https://mlsanity.com/paper/2409.03440/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 15 of its 16 references that are in the map.
- First posted on arXiv 5 Sep 2024.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 15 of 15)

- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models](https://mlsanity.com/paper/2206.04615/) (2022)
- [From Local to Global: A Graph RAG Approach to Query-Focused Summarization](https://mlsanity.com/paper/2404.16130/) (2024)
- [The Rise and Potential of Large Language Model Based Agents: A Survey](https://mlsanity.com/paper/2309.07864/) (2023)
- [Towards General Text Embeddings with Multi-stage Contrastive Learning](https://mlsanity.com/paper/2308.03281/) (2023)
- [Precise Zero-Shot Dense Retrieval without Relevance Labels](https://mlsanity.com/paper/2212.10496/) (2022)
- [Personal LLM Agents: Insights and Survey about the Capability, Efficiency and Security](https://mlsanity.com/paper/2401.05459/) (2024)
- [Take a Step Back: Evoking Reasoning via Abstraction in Large Language Models](https://mlsanity.com/paper/2310.06117/) (2023)
- [If LLM Is the Wizard, Then Code Is the Wand: A Survey on How Code Empowers Large Language Models to Serve as Intelligent Agents](https://mlsanity.com/paper/2401.00812/) (2024)
- [KG-RAG: Bridging the Gap Between Knowledge and Creativity](https://mlsanity.com/paper/2405.12035/) (2024)
- [Measuring and Reducing LLM Hallucination without Gold-Standard Answers](https://mlsanity.com/paper/2402.10412/) (2024)

## Built on by (most cited first, 7 of 7)

- [A Survey of Context Engineering for Large Language Models](https://mlsanity.com/paper/2507.13334/) (2025)
- [A Survey of LLM-based Agents in Medicine: How far are we from Baymax?](https://mlsanity.com/paper/2502.11211/) (2025)
- [Agentic AI in Healthcare & Medicine: A Seven-Dimensional Taxonomy for Empirical Evaluation of LLM-based Agents](https://mlsanity.com/paper/2602.04813/) (2026)
- [Automatic Posology Structuration : What role for LLMs?](https://mlsanity.com/paper/2506.19525/) (2025)
- [Evaluating Medical LLMs by Levels of Autonomy: A Survey Moving from Benchmarks to Applications](https://mlsanity.com/paper/2510.17764/) (2025)
- [Medication counseling with large language models: balancing flexibility and rigidity](https://mlsanity.com/paper/2601.11544/) (2025)
- [Agentic AI in medicine: architectures, applications, evaluation, and challenges for clinical translation](https://mlsanity.com/paper/2607.25489/) (2026)

## Abstract (arXiv)

To protect patient safety, modern pharmaceutical complexity demands strict prescription verification. We offer a new approach - Rx Strategist - that makes use of knowledge graphs and different search strategies to enhance the power of Large Language Models (LLMs) inside an agentic framework. This multifaceted technique allows for a multi-stage LLM pipeline and reliable information retrieval from a custom-built active ingredient database. Different facets of prescription verification, such as indication, dose, and possible drug interactions, are covered in each stage of the pipeline. We alleviate the drawbacks of monolithic LLM techniques by spreading reasoning over these stages, improving correctness and reliability while reducing memory demands. Our findings demonstrate that Rx Strategist surpasses many current LLMs, achieving performance comparable to that of a highly experienced clinical pharmacist. In the complicated world of modern medications, this combination of LLMs with organized knowledge and sophisticated search methods presents a viable avenue for reducing prescription errors and enhancing patient outcomes.