# A Multimodal Object-level Contrast Learning Method for Cancer Survival Risk Prediction

arXiv: https://arxiv.org/abs/2409.02145 · HTML: https://mlsanity.com/paper/2409.02145/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 34 references that are in the map.
- First posted on arXiv 3 Sep 2024.

## Builds on (most cited first, 13 of 13)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Unsupervised Feature Learning via Non-Parametric Instance-level Discrimination](https://mlsanity.com/paper/1805.01978/) (2018)
- [Self-Supervised Learning of Pretext-Invariant Representations](https://mlsanity.com/paper/1912.01991/) (2019)
- [DeepSurv: Personalized Treatment Recommender System Using A Cox Proportional Hazards Deep Neural Network](https://mlsanity.com/paper/1606.00931/) (2016)
- [Whole Slide Images based Cancer Survival Prediction using Attention Guided Deep Multiple Instance Learning Networks](https://mlsanity.com/paper/2009.11169/) (2020)
- [Pathomic Fusion: An Integrated Framework for Fusing Histopathology and Genomic Features for Cancer Diagnosis and Prognosis](https://mlsanity.com/paper/1912.08937/) (2019)
- [Machine Learning for Survival Analysis: A Survey](https://mlsanity.com/paper/1708.04649/) (2017)
- [Deep Recurrent Survival Analysis](https://mlsanity.com/paper/1809.02403/) (2018)
- [Bi-directional Weakly Supervised Knowledge Distillation for Whole Slide Image Classification](https://mlsanity.com/paper/2210.03664/) (2022)
- [Pathology-and-genomics Multimodal Transformer for Survival Outcome Prediction](https://mlsanity.com/paper/2307.11952/) (2023)

## Abstract (arXiv)

Computer-aided cancer survival risk prediction plays an important role in the timely treatment of patients. This is a challenging weakly supervised ordinal regression task associated with multiple clinical factors involved such as pathological images, genomic data and etc. In this paper, we propose a new training method, multimodal object-level contrast learning, for cancer survival risk prediction. First, we construct contrast learning pairs based on the survival risk relationship among the samples in the training sample set. Then we introduce the object-level contrast learning method to train the survival risk predictor. We further extend it to the multimodal scenario by applying cross-modal constrast. Considering the heterogeneity of pathological images and genomics data, we construct a multimodal survival risk predictor employing attention-based and self-normalizing based nerural network respectively. Finally, the survival risk predictor trained by our proposed method outperforms state-of-the-art methods on two public multimodal cancer datasets for survival risk prediction.