# LPUWF-LDM: Enhanced Latent Diffusion Model for Precise Late-phase UWF-FA Generation on Limited Dataset

arXiv: https://arxiv.org/abs/2409.00726 · HTML: https://mlsanity.com/paper/2409.00726/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 37 references that are in the map.
- First posted on arXiv 1 Sep 2024.

## Builds on (most cited first, 17 of 17)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [Demystifying MMD GANs](https://mlsanity.com/paper/1801.01401/) (2018)
- [High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANs](https://mlsanity.com/paper/1711.11585/) (2017)
- [Effectively Unbiased FID and Inception Score and where to find them](https://mlsanity.com/paper/1911.07023/) (2019)
- [Fast Unsupervised Brain Anomaly Detection and Segmentation with Diffusion Models](https://mlsanity.com/paper/2206.03461/) (2022)
- [Diffusion Adversarial Representation Learning for Self-supervised Vessel Segmentation](https://mlsanity.com/paper/2209.14566/) (2022)
- [Make-A-Volume: Leveraging Latent Diffusion Models for Cross-Modality 3D Brain MRI Synthesis](https://mlsanity.com/paper/2307.10094/) (2023)
- [VTGAN: Semi-supervised Retinal Image Synthesis and Disease Prediction using Vision Transformers](https://mlsanity.com/paper/2104.06757/) (2021)
- [Cycle-guided Denoising Diffusion Probability Model for 3D Cross-modality MRI Synthesis](https://mlsanity.com/paper/2305.00042/) (2023)
- [Memory-efficient GAN-based Domain Translation of High Resolution 3D Medical Images](https://mlsanity.com/paper/2010.03396/) (2020)
- [Generation of Structurally Realistic Retinal Fundus Images with Diffusion Models](https://mlsanity.com/paper/2305.06813/) (2023)
- [TauPETGen: Text-Conditional Tau PET Image Synthesis Based on Latent Diffusion Models](https://mlsanity.com/paper/2306.11984/) (2023)
- [UWAFA-GAN: Ultra-Wide-Angle Fluorescein Angiography Transformation via Multi-scale Generation and Registration Enhancement](https://mlsanity.com/paper/2405.00542/) (2024)

## Built on by (most cited first, 2 of 2)

- [Toward Medical Deepfake Detection: A Comprehensive Dataset and Novel Method](https://mlsanity.com/paper/2509.15711/) (2025)
- [BS-LDM: Effective Bone Suppression in High-Resolution Chest X-Ray Images with Conditional Latent Diffusion Models](https://mlsanity.com/paper/2412.15670/) (2024)

## Abstract (arXiv)

Ultra-Wide-Field Fluorescein Angiography (UWF-FA) enables precise identification of ocular diseases using sodium fluorescein, which can be potentially harmful. Existing research has developed methods to generate UWF-FA from Ultra-Wide-Field Scanning Laser Ophthalmoscopy (UWF-SLO) to reduce the adverse reactions associated with injections. However, these methods have been less effective in producing high-quality late-phase UWF-FA, particularly in lesion areas and fine details. Two primary challenges hinder the generation of high-quality late-phase UWF-FA: the scarcity of paired UWF-SLO and early/late-phase UWF-FA datasets, and the need for realistic generation at lesion sites and potential blood leakage regions. This study introduces an improved latent diffusion model framework to generate high-quality late-phase UWF-FA from limited paired UWF images. To address the challenges as mentioned earlier, our approach employs a module utilizing Cross-temporal Regional Difference Loss, which encourages the model to focus on the differences between early and late phases. Additionally, we introduce a low-frequency enhanced noise strategy in the diffusion forward process to improve the realism of medical images. To further enhance the mapping capability of the variational autoencoder module, especially with limited datasets, we implement a Gated Convolutional Encoder to extract additional information from conditional images. Our Latent Diffusion Model for Ultra-Wide-Field Late-Phase Fluorescein Angiography (LPUWF-LDM) effectively reconstructs fine details in late-phase UWF-FA and achieves state-of-the-art results compared to other existing methods when working with limited datasets. Our source code is available at: https://github.com/Tinysqua/****.