# RGDA-DDI: Residual graph attention network and dual-attention based framework for drug-drug interaction prediction

arXiv: https://arxiv.org/abs/2408.15310 · HTML: https://mlsanity.com/paper/2408.15310/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 33 references that are in the map.
- First posted on arXiv 27 Aug 2024.

## Builds on (most cited first, 8 of 8)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Convolutional Neural Networks on Graphs with Fast Localized Spectral Filtering](https://mlsanity.com/paper/1606.09375/) (2016)
- [DeepWalk: Online Learning of Social Representations](https://mlsanity.com/paper/1403.6652/) (2014)
- [Self-Attention Graph Pooling](https://mlsanity.com/paper/1904.08082/) (2019)
- [Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities](https://mlsanity.com/paper/1807.00123/) (2018)
- [Drug-Drug Interaction Prediction Based on Knowledge Graph Embeddings and Convolutional-LSTM Network](https://mlsanity.com/paper/1908.01288/) (2019)
- [BERT Based Clinical Knowledge Extraction for Biomedical Knowledge Graph Construction and Analysis](https://mlsanity.com/paper/2304.10996/) (2023)

## Abstract (arXiv)

Recent studies suggest that drug-drug interaction (DDI) prediction via computational approaches has significant importance for understanding the functions and co-prescriptions of multiple drugs. However, the existing silico DDI prediction methods either ignore the potential interactions among drug-drug pairs (DDPs), or fail to explicitly model and fuse the multi-scale drug feature representations for better prediction. In this study, we propose RGDA-DDI, a residual graph attention network (residual-GAT) and dual-attention based framework for drug-drug interaction prediction. A residual-GAT module is introduced to simultaneously learn multi-scale feature representations from drugs and DDPs. In addition, a dual-attention based feature fusion block is constructed to learn local joint interaction representations. A series of evaluation metrics demonstrate that the RGDA-DDI significantly improved DDI prediction performance on two public benchmark datasets, which provides a new insight into drug development.