# Histo-Diffusion: A Diffusion Super-Resolution Method for Digital Pathology with Comprehensive Quality Assessment

arXiv: https://arxiv.org/abs/2408.15218 · HTML: https://mlsanity.com/paper/2408.15218/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 48 references that are in the map.
- First posted on arXiv 27 Aug 2024.

## Builds on (most cited first, 22 of 22)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [Cascaded Diffusion Models for High Fidelity Image Generation](https://mlsanity.com/paper/2106.15282/) (2021)
- [MUSIQ: Multi-scale Image Quality Transformer](https://mlsanity.com/paper/2108.05997/) (2021)
- [Exploring CLIP for Assessing the Look and Feel of Images](https://mlsanity.com/paper/2207.12396/) (2022)
- [Real-ESRGAN: Training Real-World Blind Super-Resolution with Pure Synthetic Data](https://mlsanity.com/paper/2107.10833/) (2021)
- [Designing a Practical Degradation Model for Deep Blind Image Super-Resolution](https://mlsanity.com/paper/2103.14006/) (2021)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Towards Robust Blind Face Restoration with Codebook Lookup Transformer](https://mlsanity.com/paper/2206.11253/) (2022)
- [Learning a No-Reference Quality Metric for Single-Image Super-Resolution](https://mlsanity.com/paper/1612.05890/) (2016)
- [Re-IQA: Unsupervised Learning for Image Quality Assessment in the Wild](https://mlsanity.com/paper/2304.00451/) (2023)
- [PathLDM: Text conditioned Latent Diffusion Model for Histopathology](https://mlsanity.com/paper/2309.00748/) (2023)
- [Learned representation-guided diffusion models for large-image generation](https://mlsanity.com/paper/2312.07330/) (2023)
- [DiffMix: Diffusion Model-based Data Synthesis for Nuclei Segmentation and Classification in Imbalanced Pathology Image Datasets](https://mlsanity.com/paper/2306.14132/) (2023)
- [ViT-DAE: Transformer-driven Diffusion Autoencoder for Histopathology Image Analysis](https://mlsanity.com/paper/2304.01053/) (2023)

## Built on by (most cited first, 4 of 4)

- [Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challenges](https://mlsanity.com/paper/2505.10993/) (2025)
- [A Unified Low-level Foundation Model for Enhancing Pathology Image Quality](https://mlsanity.com/paper/2509.01071/) (2025)
- [Pathology Image Compression with Pre-trained Autoencoders](https://mlsanity.com/paper/2503.11591/) (2025)
- [Layout-Guided Controllable Pathology Image Generation with In-Context Diffusion Transformers](https://mlsanity.com/paper/2603.13386/) (2026)

## Abstract (arXiv)

Digital pathology has advanced significantly over the last decade, with Whole Slide Images (WSIs) encompassing vast amounts of data essential for accurate disease diagnosis. High-resolution WSIs are essential for precise diagnosis but technical limitations in scanning equipment and variablity in slide preparation can hinder obtaining these images. Super-resolution techniques can enhance low-resolution images; while Generative Adversarial Networks (GANs) have been effective in natural image super-resolution tasks, they often struggle with histopathology due to overfitting and mode collapse. Traditional evaluation metrics fall short in assessing the complex characteristics of histopathology images, necessitating robust histology-specific evaluation methods. We introduce Histo-Diffusion, a novel diffusion-based method specially designed for generating and evaluating super-resolution images in digital pathology. It includes a restoration module for histopathology prior and a controllable diffusion module for generating high-quality images. We have curated two histopathology datasets and proposed a comprehensive evaluation strategy which incorporates both full-reference and no-reference metrics to thoroughly assess the quality of digital pathology images. Comparative analyses on multiple datasets with state-of-the-art methods reveal that Histo-Diffusion outperforms GANs. Our method offers a versatile solution for histopathology image super-resolution, capable of handling multi-resolution generation from varied input sizes, providing valuable support in diagnostic processes.