# XDT-CXR: Investigating Cross-Disease Transferability in Zero-Shot Binary Classification of Chest X-Rays

arXiv: https://arxiv.org/abs/2408.11493 · HTML: https://mlsanity.com/paper/2408.11493/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 32 references that are in the map.
- First posted on arXiv 21 Aug 2024.

## Builds on (most cited first, 17 of 17)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Conditional Prompt Learning for Vision-Language Models](https://mlsanity.com/paper/2203.05557/) (2022)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [MaPLe: Multi-modal Prompt Learning](https://mlsanity.com/paper/2210.03117/) (2022)
- [FILIP: Fine-grained Interactive Language-Image Pre-Training](https://mlsanity.com/paper/2111.07783/) (2021)
- [MedCLIP: Contrastive Learning from Unpaired Medical Images and Text](https://mlsanity.com/paper/2210.10163/) (2022)
- [Test-Time Prompt Tuning for Zero-Shot Generalization in Vision-Language Models](https://mlsanity.com/paper/2209.07511/) (2022)
- [Self-regulating Prompts: Foundational Model Adaptation without Forgetting](https://mlsanity.com/paper/2307.06948/) (2023)
- [Align Your Prompts: Test-Time Prompting with Distribution Alignment for Zero-Shot Generalization](https://mlsanity.com/paper/2311.01459/) (2023)
- [LaFTer: Label-Free Tuning of Zero-shot Classifier using Language and Unlabeled Image Collections](https://mlsanity.com/paper/2305.18287/) (2023)
- [Learning to Prompt with Text Only Supervision for Vision-Language Models](https://mlsanity.com/paper/2401.02418/) (2024)
- [On the approximation by single hidden layer feedforward neural networks with fixed weights](https://mlsanity.com/paper/1708.06219/) (2017)
- [Multi-Label Generalized Zero Shot Learning for the Classification of Disease in Chest Radiographs](https://mlsanity.com/paper/2107.06563/) (2021)

## Built on by (most cited first, 1 of 1)

- [KEPIL: Knowledge-Enhanced Prompt-Image Learning for Prompt-Robust Disease Detection](https://mlsanity.com/paper/2605.09132/) (2026)

## Abstract (arXiv)

This study explores the concept of cross-disease transferability (XDT) in medical imaging, focusing on the potential of binary classifiers trained on one disease to perform zero-shot classification on another disease affecting the same organ. Utilizing chest X-rays (CXR) as the primary modality, we investigate whether a model trained on one pulmonary disease can make predictions about another novel pulmonary disease, a scenario with significant implications for medical settings with limited data on emerging diseases. The XDT framework leverages the embedding space of a vision encoder, which, through kernel transformation, aids in distinguishing between diseased and non-diseased classes in the latent space. This capability is especially beneficial in resource-limited environments or in regions with low prevalence of certain diseases, where conventional diagnostic practices may fail. However, the XDT framework is currently limited to binary classification, determining only the presence or absence of a disease rather than differentiating among multiple diseases. This limitation underscores the supplementary role of XDT to traditional diagnostic tests in clinical settings. Furthermore, results show that XDT-CXR as a framework is able to make better predictions compared to other zero-shot learning (ZSL) baselines.