# More Options for Prelabor Rupture of Membranes, A Bayesian Analysis

arXiv: https://arxiv.org/abs/2408.10876 · HTML: https://mlsanity.com/paper/2408.10876/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 38 references that are in the map.
- First posted on arXiv 20 Aug 2024.

## Builds on (most cited first, 4 of 4)

- [Composable Effects for Flexible and Accelerated Probabilistic Programming in NumPyro](https://mlsanity.com/paper/1912.11554/) (2019)
- [Scaling Up Differentially Private LASSO Regularized Logistic Regression via Faster Frank-Wolfe Iterations](https://mlsanity.com/paper/2310.19978/) (2023)
- [SoK: A Review of Differentially Private Linear Models For High-Dimensional Data](https://mlsanity.com/paper/2404.01141/) (2024)
- [Continuously Generalized Ordinal Regression for Linear and Deep Models](https://mlsanity.com/paper/2202.07005/) (2022)

## Built on by (most cited first, 1 of 1)

- [Adversarial Machine Learning Attacks on Financial Reporting via Maximum Violated Multi-Objective Attack](https://mlsanity.com/paper/2507.05441/) (2025)

## Abstract (arXiv)

An obstetric goal for a laboring mother is to achieve a vaginal delivery as it reduces the risks inherent in major abdominal surgery (i.e., a Cesarean section). Various medical interventions may be used by a physician to increase the likelihood of this occurring while minimizing maternal and fetal morbidity. However, patients with prelabor rupture of membranes (PROM) have only two commonly used options for cervical ripening, Pitocin and misoprostol. Little research exists on the benefits/risks for these two key drugs for PROM patients. A major limitation with most induction-of-labor related research is the inability to account for differences in textitBishop scores that are commonly used in obstetrical practice to determine the next induction agent offered to the patient. This creates a confounding factor, which biases the results, but has not been realized in the literature. In this work, we use a Bayesian model of the relationships between the relevant factors, informed by expert physicians, to separate the confounding variable from its actual impact. In doing so, we provide strong evidence that pitocin and buccal misoprostol are equally effective and safe; thus, physicians have more choice in clinical care than previously realized. This is particularly important for developing countries where neither medication may be readily available, and prior guidelines may create an artificial barrier to needed medication.