# BLADE: Benchmarking Language Model Agents for Data-Driven Science

arXiv: https://arxiv.org/abs/2408.09667 · HTML: https://mlsanity.com/paper/2408.09667/

## Key facts

- Cited by 77 papers in the map (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 23 of its 78 references that are in the map.
- First posted on arXiv 19 Aug 2024.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 23 of 23)

- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Code Llama: Open Foundation Models for Code](https://mlsanity.com/paper/2308.12950/) (2023)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [DeepSeek-Coder: When the Large Language Model Meets Programming -- The Rise of Code Intelligence](https://mlsanity.com/paper/2401.14196/) (2024)
- [DIN-SQL: Decomposed In-Context Learning of Text-to-SQL with Self-Correction](https://mlsanity.com/paper/2304.11015/) (2023)
- [Cognitive Architectures for Language Agents](https://mlsanity.com/paper/2309.02427/) (2023)
- [MLAgentBench: Evaluating Language Agents on Machine Learning Experimentation](https://mlsanity.com/paper/2310.03302/) (2023)
- [Data Interpreter: An LLM Agent For Data Science](https://mlsanity.com/paper/2402.18679/) (2024)
- [Can large language models provide useful feedback on research papers? A large-scale empirical analysis](https://mlsanity.com/paper/2310.01783/) (2023)
- [CodeS: Towards Building Open-source Language Models for Text-to-SQL](https://mlsanity.com/paper/2402.16347/) (2024)
- [InfiAgent-DABench: Evaluating Agents on Data Analysis Tasks](https://mlsanity.com/paper/2401.05507/) (2024)
- [LLM-SR: Scientific Equation Discovery via Programming with Large Language Models](https://mlsanity.com/paper/2404.18400/) (2024)
- [DS-Agent: Automated Data Science by Empowering Large Language Models with Case-Based Reasoning](https://mlsanity.com/paper/2402.17453/) (2024)
- [A comprehensive evaluation of ChatGPT's zero-shot Text-to-SQL capability](https://mlsanity.com/paper/2303.13547/) (2023)
- [Natural Language to Code Generation in Interactive Data Science Notebooks](https://mlsanity.com/paper/2212.09248/) (2022)
- [LIDA: A Tool for Automatic Generation of Grammar-Agnostic Visualizations and Infographics using Large Language Models](https://mlsanity.com/paper/2303.02927/) (2023)
- [Are LLMs Capable of Data-based Statistical and Causal Reasoning? Benchmarking Advanced Quantitative Reasoning with Data](https://mlsanity.com/paper/2402.17644/) (2024)
- [Data-driven Discovery with Large Generative Models](https://mlsanity.com/paper/2402.13610/) (2024)
- [Predicting vs. Acting: A Trade-off Between World Modeling & Agent Modeling](https://mlsanity.com/paper/2407.02446/) (2024)
- [Automated Scientific Discovery: From Equation Discovery to Autonomous Discovery Systems](https://mlsanity.com/paper/2305.02251/) (2023)
- [Tapilot-Crossing: Benchmarking and Evolving LLMs Towards Interactive Data Analysis Agents](https://mlsanity.com/paper/2403.05307/) (2024)

## Built on by (most cited first, 30 of 77)

- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers](https://mlsanity.com/paper/2409.04109/) (2024)
- [ScienceAgentBench: Toward Rigorous Assessment of Language Agents for Data-Driven Scientific Discovery](https://mlsanity.com/paper/2410.05080/) (2024)
- [Large Language Model Agent: A Survey on Methodology, Applications and Challenges](https://mlsanity.com/paper/2503.21460/) (2025)
- [From LLM Reasoning to Autonomous AI Agents: A Comprehensive Review](https://mlsanity.com/paper/2504.19678/) (2025)
- [From Automation to Autonomy: A Survey on Large Language Models in Scientific Discovery](https://mlsanity.com/paper/2505.13259/) (2025)
- [BixBench: a Comprehensive Benchmark for LLM-based Agents in Computational Biology](https://mlsanity.com/paper/2503.00096/) (2025)
- [AgentRxiv: Towards Collaborative Autonomous Research](https://mlsanity.com/paper/2503.18102/) (2025)
- [LLM Agents for Education: Advances and Applications](https://mlsanity.com/paper/2503.11733/) (2025)
- [ScienceBoard: Evaluating Multimodal Autonomous Agents in Realistic Scientific Workflows](https://mlsanity.com/paper/2505.19897/) (2025)
- [Automated Hypothesis Validation with Agentic Sequential Falsifications](https://mlsanity.com/paper/2502.09858/) (2025)
- [EXP-Bench: Can AI Conduct AI Research Experiments?](https://mlsanity.com/paper/2505.24785/) (2025)
- [KramaBench: A Benchmark for AI Systems on Data-to-Insight Pipelines over Data Lakes](https://mlsanity.com/paper/2506.06541/) (2025)
- [AutoDiscovery: Open-ended Scientific Discovery via Bayesian Surprise](https://mlsanity.com/paper/2507.00310/) (2025)
- [Large Language Model-based Data Science Agent: A Survey](https://mlsanity.com/paper/2508.02744/) (2025)
- [DAComp: Benchmarking Data Agents across the Full Data Intelligence Lifecycle](https://mlsanity.com/paper/2512.04324/) (2025)
- [Literature Meets Data: A Synergistic Approach to Hypothesis Generation](https://mlsanity.com/paper/2410.17309/) (2024)
- [RExBench: Can coding agents autonomously implement AI research extensions?](https://mlsanity.com/paper/2506.22598/) (2025)
- [FIRE-Bench: Evaluating AI Agents on the Rediscovery of Scientific Insights](https://mlsanity.com/paper/2602.02905/) (2026)
- [ResearchCodeAgent: An LLM Multi-Agent System for Automated Codification of Research Methodologies](https://mlsanity.com/paper/2504.20117/) (2025)
- [LLM-Based Multi-Agent Blackboard System for Information Discovery in Data Science](https://mlsanity.com/paper/2510.01285/) (2025)
- [DSGym: A Holistic Framework for Evaluating and Training Data Science Agents](https://mlsanity.com/paper/2601.16344/) (2026)
- [HeurekaBench: A Benchmarking Framework for AI Co-scientist](https://mlsanity.com/paper/2601.01678/) (2026)
- [AutoSDT: Scaling Data-Driven Discovery Tasks Toward Open Co-Scientists](https://mlsanity.com/paper/2506.08140/) (2025)
- [A Survey of AI Scientists](https://mlsanity.com/paper/2510.23045/) (2025)
- [AutoResearch AI: Towards AI-Powered Research Automation for Scientific Discovery](https://mlsanity.com/paper/2605.23204/) (2026)
- [DatasetResearch: Benchmarking Agent Systems for Demand-Driven Dataset Discovery](https://mlsanity.com/paper/2508.06960/) (2025)
- [BioDSA-1K: Benchmarking Data Science Agents for Biomedical Research](https://mlsanity.com/paper/2505.16100/) (2025)
- [Benchmarking AI scientists for omics data driven biological discovery](https://mlsanity.com/paper/2505.08341/) (2025)
- [Why Do Open-Source LLMs Struggle with Data Analysis? A Systematic Empirical Study](https://mlsanity.com/paper/2506.19794/) (2025)

## Abstract (arXiv)

Data-driven scientific discovery requires the iterative integration of scientific domain knowledge, statistical expertise, and an understanding of data semantics to make nuanced analytical decisions, e.g., about which variables, transformations, and statistical models to consider. LM-based agents equipped with planning, memory, and code execution capabilities have the potential to support data-driven science. However, evaluating agents on such open-ended tasks is challenging due to multiple valid approaches, partially correct steps, and different ways to express the same decisions. To address these challenges, we present BLADE, a benchmark to automatically evaluate agents' multifaceted approaches to open-ended research questions. BLADE consists of 12 datasets and research questions drawn from existing scientific literature, with ground truth collected from independent analyses by expert data scientists and researchers. To automatically evaluate agent responses, we developed corresponding computational methods to match different representations of analyses to this ground truth. Though language models possess considerable world knowledge, our evaluation shows that they are often limited to basic analyses. However, agents capable of interacting with the underlying data demonstrate improved, but still non-optimal, diversity in their analytical decision making. Our work enables the evaluation of agents for data-driven science and provides researchers deeper insights into agents' analysis approaches.