# Med42-v2: A Suite of Clinical LLMs

arXiv: https://arxiv.org/abs/2408.06142 · HTML: https://mlsanity.com/paper/2408.06142/

## Key facts

- Cited by 90 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 41 references that are in the map.
- First posted on arXiv 12 Aug 2024.

## Builds on (most cited first, 24 of 24)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [Multitask Prompted Training Enables Zero-Shot Task Generalization](https://mlsanity.com/paper/2110.08207/) (2021)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Super-NaturalInstructions: Generalization via Declarative Instructions on 1600+ NLP Tasks](https://mlsanity.com/paper/2204.07705/) (2022)
- [Enhancing Chat Language Models by Scaling High-quality Instructional Conversations](https://mlsanity.com/paper/2305.14233/) (2023)
- [Crowdsourcing Multiple Choice Science Questions](https://mlsanity.com/paper/1707.06209/) (2017)
- [The Flan Collection: Designing Data and Methods for Effective Instruction Tuning](https://mlsanity.com/paper/2301.13688/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [ToxiGen: A Large-Scale Machine-Generated Dataset for Adversarial and Implicit Hate Speech Detection](https://mlsanity.com/paper/2203.09509/) (2022)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [Explainable Automated Fact-Checking for Public Health Claims](https://mlsanity.com/paper/2010.09926/) (2020)
- [A Question-Entailment Approach to Question Answering](https://mlsanity.com/paper/1901.08079/) (2019)
- [ACI-BENCH: a Novel Ambient Clinical Intelligence Dataset for Benchmarking Automatic Visit Note Generation](https://mlsanity.com/paper/2306.02022/) (2023)
- [HEAD-QA: A Healthcare Dataset for Complex Reasoning](https://mlsanity.com/paper/1906.04701/) (2019)
- [Clinical Camel: An Open Expert-Level Medical Language Model with Dialogue-Based Knowledge Encoding](https://mlsanity.com/paper/2305.12031/) (2023)

## Built on by (most cited first, 30 of 90)

- [MMed-RAG: Versatile Multimodal RAG System for Medical Vision Language Models](https://mlsanity.com/paper/2410.13085/) (2024)
- [m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models](https://mlsanity.com/paper/2504.00869/) (2025)
- [MedHallu: A Comprehensive Benchmark for Detecting Medical Hallucinations in Large Language Models](https://mlsanity.com/paper/2502.14302/) (2025)
- [ClinicalBench: Can LLMs Beat Traditional ML Models in Clinical Prediction?](https://mlsanity.com/paper/2411.06469/) (2024)
- [MEDIC: Comprehensive Evaluation of Leading Indicators for LLM Safety and Utility in Clinical Applications](https://mlsanity.com/paper/2409.07314/) (2024)
- [MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision](https://mlsanity.com/paper/2501.12051/) (2025)
- [Benchmarking Adversarial Robustness to Bias Elicitation in Large Language Models: Scalable Automated Assessment with LLM-as-a-Judge](https://mlsanity.com/paper/2504.07887/) (2025)
- [Automating Expert-Level Medical Reasoning Evaluation of Large Language Models](https://mlsanity.com/paper/2507.07988/) (2025)
- [MMedPO: Aligning Medical Vision-Language Models with Clinical-Aware Multimodal Preference Optimization](https://mlsanity.com/paper/2412.06141/) (2024)
- [Automatic Evaluation of Healthcare LLMs Beyond Question-Answering](https://mlsanity.com/paper/2502.06666/) (2025)
- [A Modular Approach for Clinical SLMs Driven by Synthetic Data with Pre-Instruction Tuning, Model Merging, and Clinical-Tasks Alignment](https://mlsanity.com/paper/2505.10717/) (2025)
- [Lived Experience Not Found: LLMs Struggle to Align with Experts on Addressing Adverse Drug Reactions from Psychiatric Medication Use](https://mlsanity.com/paper/2410.19155/) (2024)
- [Doctor-R1: Mastering Clinical Inquiry with Experiential Agentic Reinforcement Learning](https://mlsanity.com/paper/2510.04284/) (2025)
- [Zodiac: A Cardiologist-Level LLM Framework for Multi-Agent Diagnostics](https://mlsanity.com/paper/2410.02026/) (2024)
- [Afrispeech-Dialog: A Benchmark Dataset for Spontaneous English Conversations in Healthcare and Beyond](https://mlsanity.com/paper/2502.03945/) (2025)
- [The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models](https://mlsanity.com/paper/2411.08870/) (2024)
- [OntoTune: Ontology-Driven Self-training for Aligning Large Language Models](https://mlsanity.com/paper/2502.05478/) (2025)
- [MedEthicsQA: A Comprehensive Question Answering Benchmark for Medical Ethics Evaluation of LLMs](https://mlsanity.com/paper/2506.22808/) (2025)
- [Empowering Healthcare Practitioners with Language Models: Structuring Speech Transcripts in Two Real-World Clinical Applications](https://mlsanity.com/paper/2507.05517/) (2025)
- [Multi-step retrieval and reasoning improves radiology question answering with large language models](https://mlsanity.com/paper/2508.00743/) (2025)
- [EHRStruct: A Comprehensive Benchmark Framework for Evaluating Large Language Models on Structured Electronic Health Record Tasks](https://mlsanity.com/paper/2511.08206/) (2025)
- [Assessing and Mitigating Medical Knowledge Drift and Conflicts in Large Language Models](https://mlsanity.com/paper/2505.07968/) (2025)
- [Enhancing the Medical Context-Awareness Ability of LLMs via Multifaceted Self-Refinement Learning](https://mlsanity.com/paper/2511.10067/) (2025)
- [PsychEthicsBench: Evaluating Large Language Models Against Australian Mental Health Ethics](https://mlsanity.com/paper/2601.03578/) (2026)
- [Benchmarking Multi-turn Medical Diagnosis: Hold, Lure, and Self-Correction](https://mlsanity.com/paper/2604.04325/) (2026)
- [Medical Reasoning with Large Language Models: A Survey and MR-Bench](https://mlsanity.com/paper/2604.08559/) (2026)
- [Caught in the Web of Words: Do LLMs Fall for Spin in Medical Literature?](https://mlsanity.com/paper/2502.07963/) (2025)
- [Medicine on the Edge: Comparative Performance Analysis of On-Device LLMs for Clinical Reasoning](https://mlsanity.com/paper/2502.08954/) (2025)
- [Evaluating LLMs Across Multi-Cognitive Levels: From Medical Knowledge Mastery to Scenario-Based Problem Solving](https://mlsanity.com/paper/2506.08349/) (2025)
- [Test-Time-Scaling for Zero-Shot Diagnosis with Visual-Language Reasoning](https://mlsanity.com/paper/2506.11166/) (2025)

## Abstract (arXiv)

Med42-v2 introduces a suite of clinical large language models (LLMs) designed to address the limitations of generic models in healthcare settings. These models are built on Llama3 architecture and fine-tuned using specialized clinical data. They underwent multi-stage preference alignment to effectively respond to natural prompts. While generic models are often preference-aligned to avoid answering clinical queries as a precaution, Med42-v2 is specifically trained to overcome this limitation, enabling its use in clinical settings. Med42-v2 models demonstrate superior performance compared to the original Llama3 models in both 8B and 70B parameter configurations and GPT-4 across various medical benchmarks. These LLMs are developed to understand clinical queries, perform reasoning tasks, and provide valuable assistance in clinical environments. The models are now publicly available at hrefhttps://huggingface.co/m42-healthhttps://huggingface.co/m42-health.